ArticleFrontiers in oncology2023
Redlining-associated methylation in breast tumors: the impact of contemporary structural racism on the tumor epigenome.
Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Structural racism as a leading cause of racial disparities in breast cancer quality of care outcomes: a systematic review.Frontiers in oncology · 2025Pooled it
- Experiences of Discrimination and DNA Methylation Among Black Nulliparous Women.Journal of racial and ethnic health disparities · 2026Article
- Racial Disparity in Ductal Carcinoma in Situ: Risk-Predictive and Actionable Biomarkers for Early Intervention.Cancers · 2026Review
- Historical redlining, breast cancer survival, and the mediating and modifying role of contemporary neighborhood socioeconomic conditions.American journal of epidemiology · 2026Article
- Association of DNA methyltransferase polymorphisms with breast cancer: a nested case‒control study of the Arkansas Rural Community Health study.BMC cancer · 2026Article
- Social genomics and cancer - untangling nature from nurture in squamous cell carcinoma outcomes.Frontiers in oncology · 2026Review
- Environmental exposures and epigenetic alterations in common chronic diseases: insights and challenges.Environmental epigenetics · 2026Review
- Understanding the role of neighborhood deprivation in racial disparities in triple-negative breast cancer.Cancer · 2025Article
- Living in historically redlined neighborhoods and biological aging among older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Neighborhood Opportunity and Biological Aging: Results From the Midlife in the United States.Biopsychosocial science and medicine · 2025Article
- Historical redlining and mortality in children, adolescents, and young adults with cancer in California, 2000-2019.Journal of the National Cancer Institute · 2025Article
- How multi-scale modeling can help examine social determinants of health and resulting disparities.PLoS computational biology · 2025Article
- Extending catchment area approaches to a community cancer center: a breast cancer hotspot case study.JNCI cancer spectrum · 2025Article
- Associations between experiences of discrimination and quality of life in Black breast cancer survivors.Cancer · 2025Article
- Neighborhood Environment, DNA Methylation, and Presence of Crown-Like Structures of the Breast.JAMA network open · 2025Article
- Impact of Structural Racism and Social Determinants of Health on Disparities in Breast Cancer Mortality.Cancer research · 2024Review
- Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Review
- A Multigenerational Model of Environmental Risk for Black, Indigenous, and People of Color (BIPOC) Children and Families.Environmental health perspectives · 2024Article
- The Implications of Racialized Economic Segregation and Allostatic Load on Mortality in Patients with Breast Cancer.Annals of surgical oncology · 2024Article
- Neighborhood Deprivation and DNA Methylation and Expression of Cancer Genes in Breast Tumors.JAMA network open · 2023Article
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 1 country.
Funding
Abstract
Purpose: Place-based measures of structural racism have been associated with breast cancer mortality, which may be driven, in part, by epigenetic perturbations. We examined the association between contemporary redlining, a measure of structural racism at the neighborhood level, and DNA methylation in breast tumor tissue. Methods: We identified 80 Black and White women diagnosed and treated for a first-primary breast cancer at Emory University Hospitals (2008-2017). Contemporary redlining was derived for census tracts using the Home Mortgage Disclosure Act database. Linear regression models were used to calculate the association between contemporary redlining and methylation in breast tumor tissue. We also examined epigenetic age acceleration for two different metrics, regressing β values for each cytosine-phosphate-guanine dinucleotide (CpG) site on redlining while adjusting for covariates. We employed multivariable Cox-proportional hazards models and 95% confidence intervals (CI) to estimate the association between aberrant methylation and mortality. Results: Contemporary redlining was associated with 5 CpG sites after adjustment for multiple comparisons (FDR<0.10). All genes were implicated in breast carcinogenesis, including genes related to inflammation, immune function and stress response ( Conclusion: We identified novel associations between neighborhood contemporary redlining and the breast tumor DNA methylome, suggesting that racist policies leading to inequitable social and environmental exposures, may impact the breast tumor epigenome. Additional research on the potential implications for prognosis is needed.
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