Evidence map›Paper›PMID 37621654›Full record

ArticleFrontiers in endocrinology2023

Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis.

Kaitlyn E Collins, Xiyin Wang, Yuliya Klymenko, Noah B Davis, Maria C Martinez, Chi Zhang, Kaman So, Aaron Buechlein, Douglas B Rusch, Chad J Creighton and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 15 citations in OpenAlex.

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  13. Establishment of Novel High-Grade Serous Ovarian Carcinoma Cell Line OVAR79.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Kaitlyn E CollinsDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Xiyin WangDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, United States.
Yuliya KlymenkoIndiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, United States.
Noah B DavisDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, United States.
Maria C MartinezDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, United States.
Chi ZhangDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States.
Kaman SoDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States.
Aaron BuechleinCenter for Genomics and Bioinformatics, Indiana University, Bloomington, IN, United States.
Douglas B RuschCenter for Genomics and Bioinformatics, Indiana University, Bloomington, IN, United States.
Chad J CreightonDepartment of Medicine, Baylor College of Medicine, Houston, TX, United States.
Shannon M HawkinsDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, United States.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USIndiana University Bloomington · USBaylor College of Medicine · USIndiana University Health · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Gynecologic Oncology Group Specimen BankingU24CA114793 · NCI · GYNECOLOGIC ONCOLOGY GROUP · PI DISAIA, PHILIP J. · 2005 to 2014
$7.0M
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
Indiana Medical Scientist/Engineer Training ProgramT32GM148382 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Benjamin Gaston, Emily K Sims · 2023 to 2026
$3.9M
NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709NCI NIH HHS U24 CA114793NIGMS NIH HHS T32 GM077229NIGMS NIH HHS T32 GM148382
6 · The paper itself

Abstract

Introduction: Endometriosis, a benign inflammatory disease whereby endometrial-like tissue grows outside the uterus, is a risk factor for endometriosis-associated ovarian cancers. In particular, ovarian endometriomas, cystic lesions of deeply invasive endometriosis, are considered the precursor lesion for ovarian clear-cell carcinoma (OCCC). Methods: To explore this transcriptomic landscape, OCCC from women with pathology-proven concurrent endometriosis ( Results: Analysis of protein-coding genes identified 2449 upregulated and 3131 downregulated protein-coding genes (DESeq2, Discussion: These studies in OCCC suggest that miR-10a-5p is an impactful, potentially oncogenic molecule, which warrants further studies.

Indexed as

Adenocarcinoma, Clear CellEndometriosisMicroRNAsFemaleGene Expression ProfilingHumansrap GTP-Binding ProteinsTranscriptomeMicroRNAsRAP2A protein, humanrap GTP-Binding ProteinsendometriosismiRNAovarian clear-cell carcinomaovarian endometriomatranscriptomic profiling

Identifiers

PMID37621654
PMCPMC10445169
OpenAlexW4385700870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.