ArticleAnalysis & sensing2022
Copper-Catalyzed Covalent Dimerization of Near-Infrared Fluorescent Cyanine Dyes: Synergistic Enhancement of Photoacoustic Signals for Molecular Imaging of Tumors.
Article in Analysis & sensing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Activatable smart contrast agents for photoacoustic imaging.Smart molecules : open access · 2026Review
- Targeting copper death-related long non-coding RNAs: a novel strategy to overcome immunotherapy resistance in liver cancer.Frontiers in immunology · 2026Review
- Multifunctional Nanoplatforms Bridging Diagnostics and Therapeutics in Cancer.Micromachines · 2025Review
- Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited].Biomedical optics express · 2025Review
- Targeting cuproptosis in liver cancer: Molecular mechanisms and therapeutic implications.Apoptosis : an international journal on programmed cell death · 2025Review
- 3D Multiparametric Photoacoustic Computed Tomography of Primary and Metastatic Tumors in Living Mice.ACS nano · 2024Article
- Video-rate endocavity photoacoustic/harmonic ultrasound imaging with miniaturized light delivery.Journal of biomedical optics · 2024Article
- Theoretical and experimental comparison of the performance of gold, titanium, and platinum nanodiscs as contrast agents for photoacoustic imaging.RSC advances · 2023Article
- Switchable preamplifier for dual modal photoacoustic and ultrasound imaging.Biomedical optics express · 2023Article
- Looking deep inside tissue with photoacoustic molecular probes: a review.Journal of biomedical optics · 2022Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Photoacoustic (PA) imaging relies on the absorption of light by chromophores to generate acoustic waves used to delineate tissue structures and physiology. Here, we demonstrate that Cu(II) efficiently catalyzes the dimerization of diverse near-infrared (NIR) cyanine molecules, including a peptide conjugate. NMR spectroscopy revealed a C-C covalent bond along the heptamethine chains, creating stable molecules under conditions such as a wide range of solvents and pH mediums. Dimerization achieved >90% fluorescence quenching, enhanced photostability, and increased PA signals by a factor of about 4 at equimolar concentrations compared to the monomers.
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Registered trials
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