Evidence map›Paper›PMID 37621413›Full record

ArticleMolecular therapy. Nucleic acids2023

Treatment of autosomal dominant retinitis pigmentosa caused by RHO-P23H mutation with high-fidelity Cas13X in mice.

Zixiang Yan, Yuqin Yao, Luyao Li, Lingqiong Cai, Haiwei Zhang, Shenghai Zhang, Qingquan Xiao, Xing Wang, Erwei Zuo, Chunlong Xu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Retinal organoids mirror CRISPR-Cas9 gene editing efficiency observedMolecular therapy. Methods & clinical development · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Assembling the RNA therapeutics toolbox.Medical review (2021) · 2024
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Zixiang YanShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
Yuqin YaoHuidaGene Therapeutics Co., Ltd., Shanghai 200131, China.
Luyao LiHuidaGene Therapeutics Co., Ltd., Shanghai 200131, China.
Lingqiong CaiHuidaGene Therapeutics Co., Ltd., Shanghai 200131, China.
Haiwei ZhangInstitute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China.
Shenghai ZhangDepartment of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Qingquan XiaoHuidaGene Therapeutics Co., Ltd., Shanghai 200131, China.
Xing WangHuidaGene Therapeutics Co., Ltd., Shanghai 200131, China.
Erwei ZuoShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
Chunlong XuShanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai 201210, China.
Jihong WuDepartment of Ophthalmology, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Hui YangHuidaGene Therapeutics Co., Ltd., Shanghai 200131, China.
Agricultural Genomics Institute at Shenzhen · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNChinese Academy of Sciences · CNShanghai Center for Brain Science and Brain-Inspired Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in

Indexed as

adRPhfCas13XMT: RNA/DNA editingP23H mutationretinitis pigmentosarhodopsin

Identifiers

PMID37621413
PMCPMC10445100
OpenAlexW4385621425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.