Design, synthesis, and greener pasture biological assessment of a novel nucleoside: 1-(α-D-ribofuranosyl)-6,7-difluoro-2-methyl-4-quinazolinone as an inhibitor of COVID-19 and Alzheimer's disease.

Laila M Break, Adil A Gobouri, Wafa S Al-Hsrthi, Mohamed Hagar, Nadia S Al-Kaff, Musa A Said

Open access · bronzeAbstract read

In one paragraph

Article in Turkish journal of chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 58% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Laila M BreakDepartment of Chemistry, College of Science, Taif University, Taif, Saudi Arabia.ORCID https://orcid.org/0000-0002-1072-4884

Adil A GobouriDepartment of Chemistry, College of Science, Taif University, Taif, Saudi Arabia.ORCID https://orcid.org/0000-0002-8341-959X

Wafa S Al-HsrthiDepartment of Chemistry, College of Science, Taif University, Taif, Saudi Arabia.ORCID https://orcid.org/0000-0002-4180-8036

Mohamed HagarDepartment of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt.ORCID https://orcid.org/0000-0003-0169-7738

Nadia S Al-KaffBiology Department, College of Science, Taibah University, Al-Madinah Al-Munawara, Saudi Arabia.ORCID https://orcid.org/0000-0001-8344-136X

Musa A SaidChemistry Department, College of Science, Taibah University, Al-Madinah Al-Munawara, Saudi Arabia.ORCID https://orcid.org/0000-0003-3073-5449

Taif University · SAAlexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthesis of a new fluorinated nucleoside of 6,7-difluoro-2-methyl-4-quinazolinone was described. 2-Amino-4,5-difluorobenzoic acid

Indexed as

6,7-difluoro-2-Methyl-4-quinazolinoneAlzheimer’s disease (AD)in silicoMain proteaseMD-DFT assessment

Identifiers

PMID37621349

DOI10.55730/1300-0527.3483

PMCPMC10446935

OpenAlexW4313207698

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.