Evidence map›Paper›PMID 37621133›Full record

ArticleJournal of applied clinical medical physics2023

A head and neck treatment planning strategy for a CBCT-guided ring-gantry online adaptive radiotherapy system.

Nour Nasser, George Q Yang, Jihye Koo, Mark Bowers, Kevin Greco, Vladimir Feygelman, Eduardo G Moros, Jimmy J Caudell, Gage Redler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nour NasserDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
George Q YangDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Jihye KooDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Mark BowersDepartment of Physics, University of South Florida, Tampa, Florida, USA.
Kevin GrecoDepartment of Physics, University of South Florida, Tampa, Florida, USA.
Vladimir FeygelmanDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.ORCID https://orcid.org/0000-0003-1964-2460
Eduardo G MorosDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Jimmy J CaudellDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.ORCID https://orcid.org/0000-0001-8755-9218
Gage RedlerDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Moffitt Cancer Center · USUniversity of South Florida · US

Funding

Varian Medical Systems, Palo Alto, CA
6 · The paper itself

Abstract

purposeA planning strategy was developed and the utility of online-adaptation with the Ethos CBCT-guided ring-gantry adaptive radiotherapy (ART) system was evaluated using retrospective data from Head-and-neck (H&N) patients that required clinical offline adaptation during treatment.

methodsClinical data were used to re-plan 20 H&N patients (10 sequential boost (SEQ) with separate base and boost plans plus 10 simultaneous integrated boost (SIB)). An optimal approach, robust to online adaptation, for Ethos-initial plans using clinical goal prioritization was developed. Anatomically-derived isodose-shaping helper structures, air-density override, goals for controlling hotspot location(s), and plan normalization were investigated. Online adaptation was simulated using clinical offline adaptive simulation-CTs to represent an on-treatment CBCT. Dosimetric comparisons were based on institutional guidelines for Clinical-initial versus Ethos-initial plans and Ethos-scheduled versus Ethos-adapted plans. Timing for five components of the online adaptive workflow was analyzed.

resultsThe Ethos H&N planning approach generated Ethos-initial SEQ plans with clinically comparable PTV coverage (average PTV

conclusionsWith an optimal planning approach, Ethos efficiently auto-generated dosimetrically comparable and clinically acceptable initial SEQ plans for H&N patients. Initial SIB plans were inferior and clinically unacceptable, but adapted SIB plans became clinically acceptable. Online adapted plans optimized dose to new anatomy and maintained target coverage/homogeneity with improved OAR sparing in a time-efficient manner.

Indexed as

Radiotherapy, Intensity-ModulatedSpiral Cone-Beam Computed TomographyHumansOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective StudiesHead and neck canceronline adaptive radiotherapytreatment planning

Identifiers

PMID37621133
PMCPMC10691641
OpenAlexW4386151088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.