Evidence map›Paper›PMID 37620973›Full record

ArticleAddiction (Abingdon, England)2023

The interaction of e-cigarette use and mental health symptoms on risk of cigarette smoking initiation among young adults in the United States.

Alyssa F Harlow, Dae-Hee Han, Sandrah P Eckel, Rob McConnell, Adam M Leventhal, Jessica L Barrington-Trimis

Open access · hybridAbstract read
In one paragraph

Article in Addiction (Abingdon, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alyssa F HarlowDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, California, Los Angeles, USA.ORCID 0000-0001-6744-6988
Dae-Hee HanDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, California, Los Angeles, USA.ORCID 0000-0002-2929-5928
Sandrah P EckelDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, California, Los Angeles, USA.
Rob McConnellDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, California, Los Angeles, USA.
Adam M LeventhalDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, California, Los Angeles, USA.ORCID 0000-0002-1217-525X
Jessica L Barrington-TrimisDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, California, Los Angeles, USA.ORCID 0000-0002-3331-0326
University of Southern California · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Adam Matthew Leventhal · 2018 to 2026
$39.0M
Vaping Nicotine and Cannabis Across Adolescence and Young AdulthoodR01CA229617 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE, LEVENTHAL, ADAM MATTHEW · 2019 to 2024
$4.3M
Understanding Transitions from Vaping to Smoking Across AdolescenceK01DA042950 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE · 2017 to 2021
$1.0M
The Tobacco and Cannabis Retail Environment, Neighborhood Disadvantage, and Adolescent VapingK01DA058084 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Alyssa Fitzpatrick Harlow · 2023 to 2026
$752k
NCI NIH HHS R01 CA229617NCI NIH HHS U54 CA180905NIDA NIH HHS K01 DA042950NIDA NIH HHS K01 DA058084NIDA NIH HHS L40 DA056950NIEHS NIH HHS P30 ES007048
6 · The paper itself

Abstract

BACKGROUND AND

aimsIt is unknown whether young adults who vape nicotine and have poor mental health have greater risk of smoking initiation than expected based on individual risks of vaping and mental health alone. This study aimed to estimate the joint association of vaping and mental health symptoms with smoking initiation among young adults, and test for additive interaction between vaping and mental health in smoking initiation risk.

designUsing five waves of the Population Assessment of Tobacco and Health (wave 1, 2013-2014; wave 2, 2014-2015; wave 3, 2015-2016; wave 4, 2016-2018; wave 5, 2018-2019), we estimated risk differences (RD) for the association of time-varying and time-lagged vaping and internalizing (e.g., anxiety, depressive) and externalizing (e.g., inattention/hyperactivity) mental health symptoms with cigarette smoking initiation at follow-up, over four 1-year intervals. We calculated interaction contrasts (IC) to estimate the excess risk of smoking initiation attributable to the interaction of vaping and mental health symptoms.

settingUnited States.

participantsA total of 6908 cigarette-naïve individuals aged 18-24 years. MEASUREMENTS: Exposures included current (past-30 day) vaping and internalizing and externalizing mental health symptoms (high vs moderate/low symptoms). The outcome was smoking initiation (ever cigarette use) after 1 year.

findingsThe per-interval risk of smoking initiation was 7.6% (1039 cases/13 712 person-intervals). Compared with noncurrent vaping and moderate/low mental health symptoms, adjusted RDs for current vaping and high mental health symptoms were 17.2% (95% confidence interval [CI]: 7.2% to 27.3%) for internalizing and 18.7% (95%CI: 8.1% to 29.2%) for externalizing symptoms. The excess risk attributed to interaction of current vaping and high externalizing symptoms was IC = 11.3% (95%CI: 1.3% to 21.2%; P = 0.018), with inconclusive findings for internalizing symptoms (IC = 7.7% [95%CI: -2.2% to 17.7%; P = 0.097]).

conclusionsThere is possible, but inconclusive, superadditivity between vaping and mental health in risk of smoking initiation among young adults in the United States.

Indexed as

Cigarette SmokingElectronic Nicotine Delivery SystemsTobacco ProductsVapingHumansMental HealthUnited StatesYoung Adultcigarette smokinge-cigarette useinteractionmental healthvapingyoung adults

Identifiers

PMID37620973
PMCPMC10783200
OpenAlexW4386151270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.