ArticleBMC health services research2023
Understanding reasons and determinants of medication non-adherence in community-dwelling adults: a cross-sectional study comparing young and older age groups.
Article in BMC health services research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 43 citations in OpenAlex.
- Medication Adherence in Relation to Beliefs About Medicines and Health-Related Quality of Life Among Community-Dwelling Patients: A Cross-Sectional Analysis.Journal of evaluation in clinical practice · 2026Article
- Predictors of Medication Adherence Among Taiwanese Community-Based Adults with Hypertension: The Application of Temporal Self-Regulation Theory.Behavioral sciences (Basel, Switzerland) · 2026Article
- Reassessing Ethical Considerations in Pediatric Facial Transplantation: Where Are We Now?Plastic and reconstructive surgery. Global open · 2026Article
- Efficacy and safety of switching to iGlarLixi from premixed insulin therapy in patients with type 2 diabetes: A real-world experience.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Medication reminder use and medication adherence among patients with chronic conditions in a Malaysian teaching hospital.BMC health services research · 2026Article
- Association of Health Literacy with Sociodemographic Factors and Medication Adherence Among Primary Health Care Users in Montenegro.Healthcare (Basel, Switzerland) · 2026Article
- Determinants of Medication Non-Adherence in 1,750 Indonesian Adults with Chronic Diseases: A Nationwide Cross-Sectional Study.Patient preference and adherence · 2026Article
- Longitudinal Assessment of Metabolic Syndrome and Direct-Acting Antiviral (DAA) Treatment Adherence in Hepatitis C Patients.Juntendo medical journal · 2026Article
- Medication Regimen Complexity and Patient-Reported Adherence: A Cross-Sectional Study in Internal Medicine Outpatients.Patient preference and adherence · 2026Article
- The impact of mHealth interventions on medication adherence in breast cancer: a systematic review of randomized controlled trials.Journal of pharmaceutical policy and practice · 2026Review
- A long shot? Affective temperaments predict adherence to pharmacotherapy during infertility treatment in a prospective longitudinal study.Dialogues in clinical neuroscience · 2025Article
- Indications and Outcomes of Total Hip Arthroplasty in Patients Aged 15 to 45 years.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2025Article
- Persistence with topical glaucoma therapy in Japan from the perspective of product, formulation, and patient characteristics: analysis of medical insurance claim data.BMC ophthalmology · 2025Article
- Family health history and pharmacogenomics show cross generation premature amitriptyline discontinuation is associated with CYP2C19 loss of-function enrichment.Communications medicine · 2025Article
- Medication Non-adherence in Older Adults: Underlying Factors, Potential Interventions and Outcomes.Drugs & aging · 2025Review
- Prevalence of Undiagnosed Risk Factors in Patients with First-Ever Ischemic Stroke Treated at MUHC: A Retrospective Analysis.Journal of personalized medicine · 2025Article
- Factors Influencing Medication Adherence in Heart Failure Patients-A Survey Among Cardiac Healthcare Providers.Clinical pharmacology and therapeutics · 2025Article
- Area-level socioeconomic inequalities in hypertension care cascade in China: a nationwide population-based study based on the ChinaHEART project.The Lancet regional health. Western Pacific · 2025Article
- Assessing community antibiotic usage and adherence as per standard treatment guidelines: A potential area to enhance awareness at community pharmacy settings.Exploratory research in clinical and social pharmacy · 2025Article
- Adherence to Pharmacological Treatment in Chronic Venous Disease: Results of a Real-World, Prospective, Observational Cohort Study.Life (Basel, Switzerland) · 2025Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundMedication non-adherence has become a striking problem among patients with chronic diseases worldwide. However, literature on prevalence, reasons and factors associated with medication non-adherence in Singapore general population is still lacking. This study aimed to (1) estimate the prevalence of intentional and unintentional medication non-adherence in young (aged 21-64 years) and older adults (aged ≥ 65 years), respectively; (2) identify and compare the main reasons for non-adherence; and (3) examine the association between potential factors and non-adherence in each group.
methodsThis study sampled 1,528 community-dwelling adults on medications (young adults:766, older adults: 762) from a cross-sectional population health survey conducted in the northern and central regions of Singapore in 2018/2019. Self-reported medication non-adherence and its reasons were collected using a modified questionnaire and compared between the two groups. Multiple logistic regressions were conducted to examine the association between potential factors (e.g., social-demographic factors, smoking and drinking status, presence of diabetes, hypertension, or dyslipidaemia, and presence of depressive symptoms) and medication non-adherence in each group.
resultsThe prevalence of non-adherence was 38.4% and 22.3% in young and older adults, respectively, with young adults reporting higher unintentional and intentional non-adherence rates than older adults. "Afraid of developing drug dependence" was the most common reason in both groups (young:74.8% vs. old:73.5%). Compared to young adults (3.7%), "Not understanding medication labels" was more prevalent in older adults (8.8%). Presence of depressive symptoms was associated with non-adherence in both young (odds ratio [95% confidence interval]: 3.00 [1.79, 5.05]) and older adults (4.16 [2.31, 7.51]). Being employed (2.92 [1.76, 4.84]) and taking ≥ 2 medications (1.42 [1.04, 1.95]) had positive association while personal income of SGD1,000-4,000 (0.53 [0.36, 0.77]) and current smoking (0.61 [0.39, 0.95]) had inverse association with non-compliance in young adults. Diagnosis of diabetes, hypertension, or dyslipidaemia (2.63 [1.25, 5.53]) was associated with higher odds of non-compliance in older adults.
conclusionsYoung adults had higher prevalence of medication non-adherence than older adults. The main reasons for non-adherence reported by young and older adults were generally comparable. Presence of depressive symptoms was a risk factor of medication non-adherence in both groups.
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