Evidence map›Paper›PMID 37620844›Full record

SynthesisBMC cancer2023

Prevalence of subclinical lung cancer detected at autopsy: a systematic review.

Asha Bonney, Kayo Togawa, Michelle Ng, Michael Christie, Kwun M Fong, Henry Marshall, Katharine See, Cameron Patrick, Daniel Steinfort, Renee Manser

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Asha BonneyDepartment of Respiratory and Sleep Medicine, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC, Australia. Asha.Bonney@mh.org.au.
Kayo TogawaDivision of Surveillance and Policy Evaluation, National Cancer Center Institute for Cancer Control, Tokyo, Japan.
Michelle NgCardiac Surgery Department, Austin Hospital, Heidelberg, Australia.
Michael ChristieDepartment of Anatomical Pathology, The Royal Melbourne Hospital, Melbourne, Australia.
Kwun M FongThoracic Medicine Program, The Prince Charles Hospital, Chermside, Australia.
Henry MarshallThoracic Medicine Program, The Prince Charles Hospital, Chermside, Australia.
Katharine SeeDepartment of Respiratory Medicine, Northern Hospital, Epping, Australia.
Cameron PatrickStatistical Consulting Centre, School of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.
Daniel SteinfortDepartment of Respiratory and Sleep Medicine, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC, Australia.
Renee ManserDepartment of Respiratory and Sleep Medicine, The Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC, Australia.
The Royal Melbourne Hospital · AUUniversity of Melbourne · AUAustin Hospital · AUNorthern Hospital · AUPrince Charles Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung cancer screening in high-risk populations with low-dose computed tomography is supported by international associations and recommendations. Overdiagnosis is considered a risk of screening with associated harms. The aim of this paper is to determine the prevalence of subclinical lung cancer diagnosed post-mortem to better understand the reservoir of subclinical lung cancer.

methodsWe searched EMBASE, PubMed, and MEDLINE databases from inception until March 2022 with no language restrictions. We considered all studies with ≥100 autopsies in adults. Two reviewers independently assessed eligibility of studies, extracted data, and assessed risk of bias of included studies. We performed a meta-analysis using a random-effects model for prevalence of subclinical lung cancer diagnosed post-mortem with sensitivity and subgroup analyses.

resultsA total of 13 studies with 16 730 autopsies were included. Pooled prevalence was 0.4% (95% CI 0.20 to 0.82%, I

conclusionsThis is the first published systematic review to evaluate the prevalence of post-mortem subclinical lung cancer. Compared to autopsy systematic reviews in breast, prostate and thyroid cancers, the pooled prevalence is lower in lung cancer for subclinical cancer. This result should be interpreted with caution due to the included studies risk of bias and heterogeneity, with further high-quality studies required in target screening populations.

Indexed as

Lung NeoplasmsAdultAutopsyBreastChildEarly Detection of CancerHumansMalePrevalenceAutopsyLatentLung cancerOverdiagnosisScreeningSubclinical

Identifiers

PMID37620844
PMCPMC10463584
OpenAlexW4386121219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.