Evidence map›Paper›PMID 37620743›Full record

ArticleMolecular and cellular biochemistry2024

HypoxamiR-210-3p regulates mesenchymal stem cells proliferation via P53 & Akt.

Sanjay Kumar, Varsha Yadav, Namrta Sharma, Anshika Sethi

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sanjay Kumar *Department of Biochemistry, Medical College, All India Institute of Medical Sciences, Bathinda, India. kumar.sanjay11@aiimsbathinda.edu.in.
Varsha Yadav *Department of Biochemistry, Medical College, All India Institute of Medical Sciences, Bathinda, India.
Namrta SharmaDepartment of Biochemistry, Medical College, All India Institute of Medical Sciences, Bathinda, India.
Anshika SethiDepartment of Biochemistry, Medical College, All India Institute of Medical Sciences, Bathinda, India.
All India Institute of Medical Sciences · INUniversity of Cincinnati · US

Funding

PDE5A Inhibition Stimulates Stem Cell Survival & DifferentiationR01HL095375 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ASHRAF, MUHAMMAD · 2009 to 2013
$3.2M
Department of Science and Technology, Ministry of Science and Technology, India CRG/2020/000633NIH HHS RO1 HL095375
6 · The paper itself

Abstract

Transplanted stem cells (˃95%) into ischemic myocardium die because of unfavourable conditions. Moreover, hypoxia role in the cell cycle regulation has been studied in transformed/immortalized cell lines which may have altered cell cycle regulators and/or mutated and, can't be transplanted in patients. We quest to find out the mechanism of cell cycle regulation in mesenchymal stem cells (MSC) to regulate its survival and proliferation in repair processes. Additionally, critically analysed role of hypoxamiR-210-3p, and cell cycle regulators that can regulate cell proliferation under hypoxic conditions. Bone marrow-derived MSC (BM-MSC) isolated from young male Fischer-344 rats by flushing the cavity of femur and propagated in vitro under 1% hypoxia for 72 h showed an increased in cell proliferation (

Indexed as

Cell ProliferationMesenchymal Stem CellsMicroRNAsProto-Oncogene Proteins c-aktRats, Inbred F344Tumor Suppressor Protein p53AnimalsCell HypoxiaMaleRatsMicroRNAsMIRN210 microRNA, ratProto-Oncogene Proteins c-aktTp53 protein, ratTumor Suppressor Protein p53AKTHypoxiaMesenchymal stem cellmiR-210-3pP21P53Proliferation

Identifiers

PMID37620743
OpenAlexW4386127057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.