Evidence map›Paper›PMID 37620730›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

The relationship between plasma prolactin levels and clinical manifestations with neuromyelitis optica spectrum disorders.

Hanchen Liu, Xianxing Zhang, Wei Chen, Yiwen Xu, Xiaoting Lin, Aiyu Lin

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04386018 (A Registered Cohort Study on Natural Course and Drug Efficacy of Inflammatory Demyelination Disease), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04386018 unknown statusnot on this map

A Registered Cohort Study on Natural Course and Drug Efficacy of Inflammatory Demyelination Disease

TypeobservationalSponsorNing Wang, MD., PhD.Ran2020 to 2025Enrolled400ConditionsDemyelinating Autoimmune Diseases, CNS
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Movement Disorders in MOGAD: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hanchen LiuFujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, 350004, Fujian, China.
Xianxing ZhangDepartment of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Wei ChenFujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, 350004, Fujian, China.
Yiwen XuDepartment of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Xiaoting LinDepartment of Neurology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China.
Aiyu LinFujian Key Laboratory of Molecular Neurology, Institute of Neuroscience, Fujian Medical University, Fuzhou, 350004, Fujian, China. aiyulin@fjmu.edu.cn.ORCID http://orcid.org/0000-0002-8841-2362
Fujian Medical University · CN

Funding

Joint Funds for the Innovation of Science and Technology, Fujian Province(CN) 2020Y9128Natural Science Foundation of Fujian Province 2019J01311
6 · The paper itself

Abstract

introductionSystemic prolactin levels have been found to increase in 19 patients diagnosed with neuromyelitis optica spectrum disorders (NMOSD). However, the relationship between plasma prolactin levels and clinical manifestations in NMOSD patients remains unclear.

methodsThis cross-sectional study was conducted as part of a Registered Cohort Study of Inflammatory Demyelination Disease (NCT04386018). A total of 95 patients diagnosed with central nervous system demyelinating diseases and 43 healthy controls were recruited between May 2020 and February 2022 at the First Affiliated Hospital of Fujian Medical University. Plasma samples were collected from all participants and analyzed for prolactin levels using electrochemiluminescence immunoassay. The study aimed to investigate the correlation between plasma prolactin levels and clinical features in patients with central nervous system demyelinating diseases.

resultsPlasma prolactin levels in NMOSD patients were significantly higher than those in multiple sclerosis/myelin oligodendrocyte glycoprotein antibody-associated diseases patients and controls (p<0.05, respectively), and were found to be correlated with disease activity, sensory abnormalities, thoracic spinal cord lesions, and MR lesion enhancement (p<0.05). A total of 16.28% of NMOSD patients exhibited macroprolactinemia. However, there was no correlation found between macroprolactin levels and disease activity (p>0.05).

conclusionProlactin may play a role in the pro-inflammatory regulation mechanism of NMOSD.

Indexed as

Neuromyelitis OpticaAquaporin 4AutoantibodiesCohort StudiesCross-Sectional StudiesHumansMyelin-Oligodendrocyte GlycoproteinProlactinAquaporin 4AutoantibodiesMyelin-Oligodendrocyte GlycoproteinProlactinMacroprolactinMultiple sclerosisMyelin oligodendrocyte glycoprotein antibody–associated diseasesNeuromyelitis optica spectrum disordersProlactin

Identifiers

PMID37620730
OpenAlexW4386153418

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.