Evidence map›Paper›PMID 37620532›Full record

ArticleAnnals of surgical oncology2023

Neighborhood-Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy.

Nolan M Winicki, Shannon N Radomski, Isabella S Florissi, Jordan M Cloyd, Goutam Gutta, Travis E Grotz, Christopher P Scally, Keith F Fournier, Sean P Dineen, Benjamin D Powers and 14 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Social Genomic Determinants of Health: Understanding the Molecular Pathways by Which Neighborhood Disadvantage Affects Cancer Outcomes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 11 institutions in 1 country.

Nolan M WinickiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shannon N RadomskiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Isabella S FlorissiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jordan M CloydDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Goutam GuttaDepartment of Surgery, The Ohio State University, Columbus, OH, USA.
Travis E GrotzDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Christopher P ScallyDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Keith F FournierDepartment of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sean P DineenDepartment of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Benjamin D PowersDepartment of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Jula VeerapongDepartment of Surgery, UC San Diego School of Medicine, La Jolla, CA, USA.
Joel M BaumgartnerDepartment of Surgery, UC San Diego School of Medicine, La Jolla, CA, USA.
Callisia N ClarkeDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Anai N KothariDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Ugwuji N MaduekweDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Sameer H PatelDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Gregory C WilsonDepartment of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Patrick SchwartzDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Patrick R VarleyDepartment of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Mustafa RaoofDepartment of Surgery, City of Hope, Duarte, CA, USA.
Byrne LeeDepartment of Surgery, Stanford University, Palo Alto, CA, USA.
Ibrahim MalikDepartment of Surgery, City of Hope, Duarte, CA, USA.
Fabian M JohnstonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jonathan B GreerDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jgreer13@jhmi.edu.ORCID http://orcid.org/0000-0001-8968-9710
Johns Hopkins University · USMedical College of Wisconsin · USCity of Hope · USMoffitt Cancer Center · USThe Ohio State University · USThe University of Texas MD Anderson Cancer Center · USUniversity of California San Diego · USUniversity of Cincinnati Medical Center · USUniversity of Wisconsin–Madison · USMayo Clinic in Arizona · USStanford University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Clinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0M
NCI NIH HHS 5T32CA126607-12NCI NIH HHS P30 CA006973NCI NIH HHS T32 CA126607
6 · The paper itself

Abstract

backgroundCytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves survival in select patients with peritoneal metastases (PM), but the impact of social determinants of health on CRS/HIPEC outcomes remains unclear. PATIENTS AND

methodsA retrospective review was conducted of a multi-institutional database of patients with PM who underwent CRS/HIPEC in the USA between 2000 and 2017. The area deprivation index (ADI) was linked to the patient's residential address. Patients were categorized as living in low (1-49) or high (50-100) ADI residences, with increasing scores indicating higher socioeconomic disadvantage. The primary outcome was overall survival (OS). Secondary outcomes included perioperative complications, hospital/intensive care unit (ICU) length of stay (LOS), and disease-free survival (DFS).

resultsAmong 1675 patients 1061 (63.3%) resided in low ADI areas and 614 (36.7%) high ADI areas. Appendiceal tumors (n = 1102, 65.8%) and colon cancer (n = 322, 19.2%) were the most common histologies. On multivariate analysis, high ADI was not associated with increased perioperative complications, hospital/ICU LOS, or DFS. High ADI was associated with worse OS (median not reached versus 49 months; 5 year OS 61.0% versus 28.2%, P < 0.0001). On multivariate Cox-regression analysis, high ADI (HR, 2.26; 95% CI 1.13-4.50; P < 0.001), cancer recurrence (HR, 2.26; 95% CI 1.61-3.20; P < 0.0001), increases in peritoneal carcinomatosis index (HR, 1.03; 95% CI 1.01-1.05; P < 0.001), and incomplete cytoreduction (HR, 4.48; 95% CI 3.01-6.53; P < 0.0001) were associated with worse OS.

conclusionsEven after controlling for cancer-specific variables, adverse outcomes persisted in association with neighborhood-level socioeconomic disadvantage. The individual and structural-level factors leading to these cancer disparities warrant further investigation to improve outcomes for all patients with peritoneal malignancies.

Indexed as

Colorectal NeoplasmsHyperthermia, InducedPeritoneal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsCombined Modality TherapyCytoreduction Surgical ProceduresHumansHyperthermic Intraperitoneal ChemotherapyNeoplasm Recurrence, LocalRetrospective StudiesSocioeconomic Disparities in HealthSurvival Rate

Identifiers

PMID37620532
PMCPMC10592201
OpenAlexW4386121849

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.