Evidence map›Paper›PMID 37620452›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2023

Sars-Cov-2 Infection in People with Type 1 Diabetes and Hospital Admission: An Analysis of Risk Factors for England.

Adrian H Heald, David A Jenkins, Richard Williams, Rajshekhar N Mudaliar, Amber Khan, Akheel Syed, Naveed Sattar, Kamlesh Khunti, Asma Naseem, Kelly A Bowden-Davies and 3 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Adrian H HealdThe School of Medicine-Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK. adrian.heald@manchester.ac.uk.ORCID http://orcid.org/0000-0002-9537-4050
David A JenkinsDivision of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Richard WilliamsDivision of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Rajshekhar N MudaliarDepartment of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, UK.
Amber KhanDepartment of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, UK.
Akheel SyedThe School of Medicine-Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.
Naveed SattarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Kamlesh KhuntiDiabetes Research Centre, University of Leicester, Leicester, UK.
Asma NaseemDepartment of Diabetes and Endocrinology, Salford Royal NHS Foundation Trust, Salford, UK.
Kelly A Bowden-DaviesDepartment of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, UK.
J Martin GibsonThe School of Medicine-Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.
William OllierFaculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK.
CVD-COVID-UK/COVID-IMPACT Consortium
Manchester Academic Health Science Centre · GBSalford Royal NHS Foundation Trust · GBManchester Metropolitan University · GBUniversity of Glasgow · GBUniversity of Leicester · GB

Funding

British Heart Foundation SP/19/3/34678Medical Research Council MC_PC_20058
6 · The paper itself

Abstract

introductionThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus (coronavirus disease 2019 [COVID-19]) pandemic revealed the vulnerability of specific population groups in relation to susceptibility to acute deterioration in their health, including hospital admission and mortality. There is less data on outcomes for people with type 1 diabetes (T1D) following SARS-CoV-2 infection than for those with type 2 diabetes (T2D). In this study we set out to determine the relative likelihood of hospital admission following SARS-CoV-2 infection in people with T1D when compared to those without T1D.

methodsThis study was conducted as a retrospective cohort study and utilised an all-England dataset. Electronic health record data relating to people in a national England database (NHS England's Secure Data Environment, accessed via the BHF Data Science Centre's CVD-COVID-UK/COVID-IMPACT consortium) were analysed. The cohort consisted of patients with a confirmed SARS-CoV-2 infection, and the exposure was whether or not an individual had T1D prior to infection (77,392 patients with T1D). The patients without T1D were matched for sex, age and approximate date of the positive COVID-19 test, with three SARS-CoV-2-infected people living without diabetes (n = 223,995). Potential factors influencing the relative likelihood of the outcome of hospital admission within 28 days were ascertained using univariable and multivariable logistic regression.

resultsMedian age of the people living with T1D was 37 (interquartile range 25-52) years, 47.4% were female and 89.6% were of white ethnicity. Mean body mass index was 27 (standard error [SE] 0.022) kg/m

conclusionIn this all-England study, we describe that, following confirmed infection with SARS-CoV-2, the risk factors for hospital admission for people living with T1D are similar to people without diabetes following confirmed SARS-CoV-2 infection, although the former were more likely to be admitted to hospital. The younger age of individuals with T1D in relation to risk stratification must be taken into account in any ongoing risk reduction strategies regarding COVID-19/future viral pandemics.

Indexed as

COVID-19OutcomeSARS-CoV-2Type 1 diabetes

Identifiers

PMID37620452
PMCPMC10597906
OpenAlexW4386125483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.