Evidence map›Paper›PMID 37620375›Full record

ArticleScientific reports2023

Investigation of microstructural failure in the human cornea through fracture tests.

Sai Naga Sri Harsha Chittajallu, Himanshu Gururani, Kwong Ming Tse, Subha Narayan Rath, Sayan Basu, Viswanath Chinthapenta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sai Naga Sri Harsha ChittajalluDepartment of Mechanical and Aerospace Engineering, Indian Institute of Technology Hyderabad (IIT Hyderabad), Hyderabad, India.
Himanshu GururaniDepartment of Mechanical and Aerospace Engineering, Indian Institute of Technology Hyderabad (IIT Hyderabad), Hyderabad, India.
Kwong Ming TseDepartment of Mechanical and Product Design Engineering, Swinburne University of Technology, Melbourne, Australia.
Subha Narayan RathDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, India.
Sayan BasuProf. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.
Viswanath ChinthapentaDepartment of Mechanical and Aerospace Engineering, Indian Institute of Technology Hyderabad (IIT Hyderabad), Hyderabad, India. viswanath@mae.iith.ac.in.
Indian Institute of Technology Hyderabad · INL V Prasad Eye Institute · INSwinburne University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fracture toughness of the human cornea is one of the critical parameters in suture-involved corneal surgeries and the development of bioengineered mimetics of the human cornea. The present article systematically studied the fracture characteristics of the human cornea to evaluate its resistance to tear in the opening (Mode-I) and trouser tear mode (Mode-III). Tear experiments reveal the dependency of the fracture behavior on the notch size and its location created in the corneal specimens. The findings indicate lamellar tear and collagen fiber pull-out as a failure mechanism in trouser tear and opening mode tests, respectively. Experimental results have shown a localized variation of tear behavior in trouser tear mode and indicated an increasing resistance to tear from the corneal center to the periphery. This article demonstrated the complications of evaluating fracture toughness in opening mode and showed that the limbus was weaker than the cornea and sclera against tearing. The overall outcomes of the present study help in designing experiments to understand the toughness of the diseased tissues, understanding the effect of the suturing location and donor placement, and creating numerical models to study parameters affecting corneal replacement surgery.

Indexed as

Fractures, BoneLacerationsBiomedical EngineeringCorneaExtracellular MatrixHumans

Identifiers

PMID37620375
PMCPMC10449857
OpenAlexW4386135296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.