Evidence map›Paper›PMID 37620363›Full record

ArticleScientific reports2023

Cross-species comparative analysis of single presynapses.

Eloïse Berson, Chandresh R Gajera, Thanaphong Phongpreecha, Amalia Perna, Syed A Bukhari, Martin Becker, Alan L Chang, Davide De Francesco, Camilo Espinosa, Neal G Ravindra and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Eloïse BersonDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
Chandresh R GajeraDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
Thanaphong PhongpreechaDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
Amalia PernaDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
Syed A BukhariDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
Martin BeckerDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
Alan L ChangDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
Davide De FrancescoDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
Camilo EspinosaDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
Neal G RavindraDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
Nadia PostupnaDepartment of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
Caitlin S LatimerDepartment of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
Carol A ShivelyDepartment of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Thomas C RegisterDepartment of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Suzanne CraftDepartment of Internal Medicine-Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kathleen S MontineDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
Edward J FoxDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA.
C Dirk KeeneDepartment of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
Sean C BendallDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
Nima AghaeepourDepartment of Anesthesiology, Perioperative, and Pain Medicine, Stanford University, Stanford, CA, USA.
Thomas J MontineDepartment of Pathology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94304, USA. tmontine@stanford.edu.
Stanford Medicine · USStanford University · USUniversity of Washington · USWake Forest University · US

Funding

Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Linda Kathleen McEvoy · 2021 to 2026
$80.4M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WILLIAMSON, JEFF DOUGLAS · 2016 to 2020
$12.2M
Dietary Mitigation of Psychosocial Stress Effects on CVD Risk R01HL087103 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHIVELY, CAROL A. · 2007 to 2017
$6.0M
MIRIAD - Multiplexed Imaging of Resilience In Alzheimers DiseaseR01AG057915 · NIA · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2017 to 2021
$4.5M
Neuropathologic substrates for motor and cognitive impairment in three existing cohort studies of Alzheimer's disease and related dementiasUF1AG057707 · NIA · STANFORD UNIVERSITY · PI MONTINE, THOMAS J, WHITE, LON RAY · 2017 to 2017
$3.9M
Deciphering the Glycan Code in Human Alzheimer’s Disease BrainR01AG078702 · NIA · UNIVERSITY OF KENTUCKY · PI Peggi M Angel, Sean Curtis Bendall · 2022 to 2026
$3.8M
Effects of Western and Mediterranean Diets on Metabolic and Neuropathologic Risk Factors for Alzheimer's Disease in Nonhuman PrimatesRF1AG058829 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CRAFT, SUZANNE, SHIVELY, CAROL A. · 2018 to 2018
$2.8M
The Phenotypic Landscape of Cognitive Decline as Revealed by Next-Generation Multiplexed Ion Beam ImagingR01AG056287 · NIA · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2017 to 2021
$2.6M
Machine Learning for Integrative Modeling of the Immune System in Clinical SettingsR35GM138353 · NIGMS · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA · 2020 to 2024
$2.2M
Neuropathology of synapses in AD and ADRDRF1AG077443 · NIA · STANFORD UNIVERSITY · PI AGHAEEPOUR, NIMA, MONTINE, THOMAS J · 2023 to 2023
$2.2M
NCRR NIH HHS S10 RR027431NHLBI NIH HHS R01 HL087103NHLBI NIH HHS R01 HL122393NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG056287NIA NIH HHS R01 AG057915NIA NIH HHS R01 AG068279NIA NIH HHS R01 AG077443NIA NIH HHS R01 AG078702NIA NIH HHS RF1 AG058829NIA NIH HHS RF1 AG077443NIA NIH HHS U19 AG066567NIA NIH HHS UF1 AG057707NIGMS NIH HHS R35 GM138353
6 · The paper itself

Abstract

Comparing brain structure across species and regions enables key functional insights. Leveraging publicly available data from a novel mass cytometry-based method, synaptometry by time of flight (SynTOF), we applied an unsupervised machine learning approach to conduct a comparative study of presynapse molecular abundance across three species and three brain regions. We used neural networks and their attractive properties to model complex relationships among high dimensional data to develop a unified, unsupervised framework for comparing the profile of more than 4.5 million single presynapses among normal human, macaque, and mouse samples. An extensive validation showed the feasibility of performing cross-species comparison using SynTOF profiling. Integrative analysis of the abundance of 20 presynaptic proteins revealed near-complete separation between primates and mice involving synaptic pruning, cellular energy, lipid metabolism, and neurotransmission. In addition, our analysis revealed a strong overlap between the presynaptic composition of human and macaque in the cerebral cortex and neostriatum. Our unique approach illuminates species- and region-specific variation in presynapse molecular composition.

Indexed as

BrainSynaptic TransmissionAnimalsCerebral CortexHumansLipid MetabolismMacacaMice

Identifiers

PMID37620363
PMCPMC10449792
OpenAlexW4386120985

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.