Evidence map›Paper›PMID 37620357›Full record

ArticleScientific data2023

A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics.

Philippe Weitz, Masi Valkonen, Leslie Solorzano, Circe Carr, Kimmo Kartasalo, Constance Boissin, Sonja Koivukoski, Aino Kuusela, Dusan Rasic, Yanbo Feng and 8 more

Abstract readDataset
In one paragraph

Article in Scientific data, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. The Genomic and Biologic Landscapes of Breast Cancer and Racial Differences.International journal of molecular sciences · 2024
    Review
  9. Article
  10. Quilt-1M: One Million Image-Text Pairs for Histopathology.Advances in neural information processing systems · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Philippe Weitz *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. philippe.weitz@ki.se.ORCID http://orcid.org/0000-0002-1788-0716
Masi Valkonen *Institute of Biomedicine, University of Turku, Turku, Finland.ORCID http://orcid.org/0000-0003-3091-2484
Leslie Solorzano *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Circe CarrInstitute of Biomedicine, University of Turku, Turku, Finland.
Kimmo KartasaloDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-9470-4783
Constance BoissinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sonja KoivukoskiInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-4909-3522
Aino KuuselaInstitute of Biomedicine, University of Turku, Turku, Finland.
Dusan RasicDepartment of Surgical Pathology, Zealand University Hospital, Roskilde, Denmark.ORCID http://orcid.org/0000-0003-4610-5265
Yanbo FengDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sandra Sinius PouplierDepartment of Surgical Pathology, Zealand University Hospital, Roskilde, Denmark.ORCID http://orcid.org/0000-0002-2625-7440
Abhinav SharmaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kajsa Ledesma ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Leena LatonenInstitute of Biomedicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0003-4502-2193
Anne-Vibeke LaenkholmDepartment of Surgical Pathology, Zealand University Hospital, Roskilde, Denmark.
Johan Hartman *Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6500-8527
Pekka Ruusuvuori *Institute of Biomedicine, University of Turku, Turku, Finland.
Mattias Rantalainen *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. mattias.rantalainen@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The analysis of FFPE tissue sections stained with haematoxylin and eosin (H&E) or immunohistochemistry (IHC) is essential for the pathologic assessment of surgically resected breast cancer specimens. IHC staining has been broadly adopted into diagnostic guidelines and routine workflows to assess the status of several established biomarkers, including ER, PGR, HER2 and KI67. Biomarker assessment can also be facilitated by computational pathology image analysis methods, which have made numerous substantial advances recently, often based on publicly available whole slide image (WSI) data sets. However, the field is still considerably limited by the sparsity of public data sets. In particular, there are no large, high quality publicly available data sets with WSIs of matching IHC and H&E-stained tissue sections from the same tumour. Here, we publish the currently largest publicly available data set of WSIs of tissue sections from surgical resection specimens from female primary breast cancer patients with matched WSIs of corresponding H&E and IHC-stained tissue, consisting of 4,212 WSIs from 1,153 patients.

Indexed as

Breast NeoplasmsBreastColoring AgentsEosine Yellowish-(YS)FemaleHematoxylinHumansStaining and LabelingColoring AgentsEosine Yellowish-(YS)Hematoxylin

Identifiers

PMID37620357
PMCPMC10449765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.