ArticleNature communications2023
Synthesis of robust underwater glues from common proteins via unfolding-aggregating strategy.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Multiple-layer mesh from electrospinnable amyloid‑like protein and their application in treating oral ulcer.Nature communications · 2026Article
- Macroscopic assembly of supramolecular coacervates for underwater adhesion.Nature communications · 2026Article
- Superspreading and ultra-infiltrative coacervate mediates strong underwater adhesion on hydrated and lipidic substrates.Nature chemistry · 2026Article
- Robust water-activated tissue adhesive patch for arterial/heart wound closure after intervention surgery.Nature communications · 2026Article
- Effect of Salts on the Aggregation and Strength of Protein-Based Underwater Adhesives.ACS omega · 2025Article
- Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine.Exploration (Beijing, China) · 2025Review
- Preserving fruit freshness with amyloid-like protein coatings.Nature communications · 2025Article
- Chain entanglement enhanced strong and tough wool keratin/albumin fibers for bioabsorbable and immunocompatible surgical sutures.Nature communications · 2025Article
- Molecular self-assembly strategy tuning a dry crosslinking protein patch for biocompatible and biodegradable haemostatic sealing.Nature communications · 2025Article
- Advances in adhesion interfaces of peripheral nerve repair materials: mechanism, classification, evaluation method, and functionalization.Frontiers in cell and developmental biology · 2025Review
- Pharmacological effects and application prospects of mussel adhesive proteins.Frontiers in pharmacology · 2025Review
- An Overview on the Adhesion Mechanisms of Typical Aquatic Organisms and the Applications of Biomimetic Adhesives in Aquatic Environments.International journal of molecular sciences · 2024Review
- Design of a Facile Antifouling Sensor Based on the Synergy between an Antibody and Phase-Transited BSA.Biosensors · 2023Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Underwater adhesive proteins secreted by organisms greatly inspires the development of underwater glue. However, except for specific proteins such as mussel adhesive protein, barnacle cement proteins, curli protein and their related recombinant proteins, it is believed that abundant common proteins cannot be converted into underwater glue. Here, we demonstrate that unfolded common proteins exhibit high affinity to surfaces and strong internal cohesion via amyloid-like aggregation in water. Using bovine serum albumin (BSA) as a model protein, we obtain a stable unfolded protein by cleaving the disulfide bonds and maintaining the unfolded state by means of stabilizing agents such as trifluoroethanol (TFE) and urea. The diffusion of stabilizing agents into water exposes the hydrophobic residues of an unfolded protein and initiates aggregation of the unfolded protein into a solid block. A robust and stable underwater glue can thus be prepared from tens of common proteins. This strategy deciphers a general code in common proteins to construct robust underwater glue from abundant biomass.
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