ArticleNature communications2023
Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed.
- Biological Rhythms in Coronavirus Pneumonia Pathogenesis.Journal of biological rhythms · 2026Article
- Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis.PLoS medicine · 2026Article
- Combined nocturnal sleep pattern and napping duration in relation to metabolic dysfunction-associated steatotic liver disease risk and prediction in type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2026Article
- Article
- A Fully Self-Powered Digital Wearable System for the Auxiliary Treatment of Plantar Fasciitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- HairTime: A noninvasive assay for estimating circadian phase from a single hair sample.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sleep and temperature data from wearable devices support noninvasive detection of diabetes mellitus in a large-scale, retrospective analysis.Communications medicine · 2026Article
- Evaluating the Accuracy of Declared Eating Schedules by Continuous Glucose Monitoring.Nutrients · 2026Article
- Quantifying Sleep-Wake Rhythms in the Hospital Environment with Digital Technologies.medRxiv : the preprint server for health sciences · 2025Article
- Critically ill patients with a reverse blood pressure dipping phenotype at increased risk for delirium and death.Scientific reports · 2025Article
- Diurnal variation of wearable device-based heart rate variability in the Chronic Renal Insufficiency Cohort study.NPJ digital medicine · 2025Article
- Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials.Annals of intensive care · 2025Article
- Association between skin temperature variability and sleep apnea severity: findings from a pilot study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Health risks and genetic architecture of objectively measured multidimensional sleep health.Nature communications · 2025Article
- Phenome-wide associations of sleep characteristics in the Human Phenotype Project.Nature medicine · 2025Article
- Article
- Wearables in Chronomedicine and Interpretation of Circadian Health.Diagnostics (Basel, Switzerland) · 2025Review
- Age- and sex-related differences in sleep patterns and their relations to self-reported sleep and mood.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Sex- and Substance-Specific Associations of Circadian-Related Genes with Addiction in the UK Biobank Cohort Implicate Neuroplasticity Pathways.Brain sciences · 2024Article
- Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo.Nature communications · 2024Article
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Abstract
Many chronic disease symptomatologies involve desynchronized sleep-wake cycles, indicative of disrupted biorhythms. This can be interrogated using body temperature rhythms, which have circadian as well as sleep-wake behavior/environmental evoked components. Here, we investigated the association of wrist temperature amplitudes with a future onset of disease in the UK Biobank one year after actigraphy. Among 425 disease conditions (range n = 200-6728) compared to controls (range n = 62,107-91,134), a total of 73 (17%) disease phenotypes were significantly associated with decreased amplitudes of wrist temperature (Benjamini-Hochberg FDR q < 0.05) and 26 (6.1%) PheCODEs passed a more stringent significance level (Bonferroni-correction α < 0.05). A two-standard deviation (1.8° Celsius) lower wrist temperature amplitude corresponded to hazard ratios of 1.91 (1.58-2.31 95% CI) for NAFLD, 1.69 (1.53-1.88) for type 2 diabetes, 1.25 (1.14-1.37) for renal failure, 1.23 (1.17-1.3) for hypertension, and 1.22 (1.11-1.33) for pneumonia (phenome-wide atlas available at http://bioinf.itmat.upenn.edu/biorhythm_atlas/ ). This work suggests peripheral thermoregulation as a digital biomarker.
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