Evidence map›Paper›PMID 37620152›Full record

ArticleESC heart failure2023

GDF-15 at admission predicts cardiovascular death, heart failure, and bleeding outcomes in patients with CAD.

Jiali Wang, Tao Zhang, Feng Xu, Wei Gao, Ming Chen, Huadong Zhu, Jun Xu, Xinxin Yin, Jiaojiao Pang, Song Zhang and 6 more

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04044066 (BIomarker-based Prognostic Assessment for Patients With Stable Angina and Acute Coronary Syndromes), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04044066 unknown statusnot on this map

BIomarker-based Prognostic Assessment for Patients With Stable Angina and Acute Coronary Syndromes (BIPass)

Typeobservational_patient_registrySponsorQilu Hospital of Shandong UniversityRan2017 to 2020Enrolled10,000ConditionsAcute Coronary Syndrome, Stable AnginaArmsPlasma biomarker
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jiali WangDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
Tao ZhangShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China.
Feng XuDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
Wei GaoDepartment of Cardiology, Peking University Third Hospital, Beijing, China.
Ming ChenDepartment of Cardiology, Peking University First Hospital, Beijing, China.
Huadong ZhuDepartment of Emergency, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Jun XuDepartment of Emergency, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Xinxin YinDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
Jiaojiao PangDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
Song ZhangDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.
Mengke WeiShandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, China.
Jiahao ChenDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ying LiuDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xuezhong YuDepartment of Emergency, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Derek P ChewDepartment of Cardiovascular Medicine, Flinders University, Adelaide, Australia.
Yuguo ChenDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, China.

Funding

ECCM Program of Clinical Research Center of Shandong University 2021SDUCRCA005Key Research and Development Program of Shandong Province 2021SFGC0503Key Research and Development Program of Shandong Province 2021ZLGX02National Key Research and Development Program of China 2020YFC1512700National Key Research and Development Program of China 2020YFC1512703National Key Research and Development Program of China 2020YFC1512705National Science and Technology Fundamental Resources Investigation Project 2018FY100600National Science and Technology Fundamental Resources Investigation Project 2018FY100602Taishan Pandeng Scholar Program of Shandong Province tspd20181220Taishan Young Scholar Program of Shandong Province tsqn20161065Taishan Young Scholar Program of Shandong Province tsqn201812129Youth Top-Talent Project of National Ten Thousand Talents Plan and Qilu Young Scholar Program
6 · The paper itself

Abstract

aimsWe aimed to investigate the independent associations between growth differentiation factor 15 (GDF-15) level at admission and cardiovascular (CV) death, thrombotic events, heart failure (HF), and bleeding outcomes in patients with coronary artery disease (CAD). METHODS AND

resultsWe measured the plasma concentrations of GDF-15 centrally in patients from the BIomarker-based Prognostic Assessment for patients with Stable angina and acute coronary Syndrome (BIPass) registry, which consecutively enrolled patients with CAD from November 2017 to September 2019 at five tertiary hospitals in China. The outcomes included CV death, thrombotic events [myocardial infarction (MI) and ischaemic stroke], HF events [acute HF during hospitalization and hospitalization for HF post-discharge (A/H HF) and cardiogenic shock], and bleeding outcomes [non-coronary artery bypass grafting-related major bleeding and clinically significant bleeding (CSB)] during the 12 month follow-up period after hospitalization. Among 6322 patients with CAD {65.4% male, median age 63.7 [inter-quartile range (IQR)] 56.0-70.1 years}, the median concentration of plasma GDF-15 at admission was 1091 (IQR 790.5-1635.0) ng/L. Higher concentrations of GDF-15 were associated with an increased risk of CV death [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.35-2.88, P < 0.001], A/H HF (HR 2.69, 95% CI 1.92-3.77, P < 0.001), cardiogenic shock (HR 1.46, 95% CI 1.04-2.05, P = 0.029), and CSB (HR 1.48, 95% CI 1.22-1.79, P < 0.001), but not for MI or stroke, after adjusting for clinical risk factors and prognostic biomarkers. Adding GDF-15 to the model with risk factors and biomarkers improved the net reclassification for CV death, A/H HF, cardiogenic shock, and CSB.

conclusionsIn patients with CAD, admission levels of GDF-15 were associated with an increased 1 year risk of CV death, HF, and bleeding outcomes, but not with thrombotic events. GDF-15 may be a prognostic biomarker for CV death, HF, and bleeding outcomes and could be used to refine the risk assessment of these specific clinical outcomes.

trial registrationClinicalTrials.gov Identifier: NCT04044066.

Indexed as

Coronary Artery DiseaseGrowth Differentiation Factor 15Heart FailureHemorrhageRegistriesAgedBiomarkersCause of DeathChinaFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient AdmissionPrognosisBiomarkersGDF15 protein, humanGrowth Differentiation Factor 15BiomarkerClinical outcomesCoronary artery diseaseGrowth differentiation factor 15Prognostic value

Identifiers

PMID37620152
PMCPMC10567639

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.