ArticlePhysiological reports2023
Sex differences in skeletal muscle size, function, and myosin heavy chain isoform expression during post-injury regeneration in mice.
Article in Physiological reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Loss of ovarian hormones modulates sex-specific metabolic adaptations to volumetric muscle loss.American journal of physiology. Cell physiology · 2026Article
- Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans.The Journal of physiology · 2025Article
- Estrogen Receptor Regulates Male Satellite Cells in a Female, but Not Male, Environment.Cells · 2025Article
- Variations of sex-hormones in reproductive aged females do not impact the repeated bout effect following maximal unaccustomed eccentric exercise of the elbow flexors.Biology of sport · 2025Article
- Ablation of UCP-1+ cells impacts FAP dynamics in muscle regeneration.American journal of physiology. Cell physiology · 2025Article
- Extensive differential gene expression and regulation by sex in human skeletal muscle.Cell genomics · 2025Article
- Evaluation of biological sex on endstage pathobiology and regenerative treatment of volumetric muscle loss.Scientific reports · 2025Article
- Differential transcriptomic profiling of lipid metabolism and collagen remodeling in fast- and slow-twitch skeletal muscles in aging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Effects of Aging on Intramuscular Collagen-Related Factors After Injury to Mouse Tibialis Anterior Muscle.International journal of molecular sciences · 2025Article
- Fibroblast growth factor-inducible 14 regulates satellite cell self-renewal and expansion during skeletal muscle repair.bioRxiv : the preprint server for biology · 2025Article
- Differential evaluation of neuromuscular injuries to understand re-innervation at the neuromuscular junction.Experimental neurology · 2024Article
- Article
- Histological and biochemical changes in lymphatic vessels after skeletal muscle injury induced by lengthening contraction in male mice.Physiological reports · 2024Article
- Exercise and Caloric Restriction Exert Different Benefits on Skeletal Muscle Metabolism in Aging Condition.Nutrients · 2023Article
- Sex differences in skeletal muscle size, function, and myosin heavy chain isoform expression during post-injury regeneration in mice.Physiological reports · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Skeletal muscle regeneration is an essential process to restore muscle function after injury and is influenced by various factors. Despite the known importance of sex hormones in muscle regeneration, whether and what sex difference exists in this process is still unclear. In this study, we provide evidence for a clear sex difference in muscle regeneration in mice. At 7 and 14 days after barium chloride-induced muscle injury, female mice showed a faster recovery of muscle fiber size than males. Consistently, muscle force in female mice was restored faster than in males after injury, and this functional difference was maintained at 14 months of age when regenerative capacity declined. Myosin heavy chain isoform profiling and fatigability test revealed dynamic remodeling of myosin heavy chain isoform expression including a type IIB to IIA/X MHC transition and reduced fatigability in regenerated muscles compared to uninjured muscles. A significant sex difference was detected in myosin heavy chain IIX content, although this did not lead to different fatigability. Together, our results suggest that sex is an important determinant of the recovery of regenerating skeletal muscle and is partially involved in the remodeling of myosin heavy chain isoforms during muscle regeneration.
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