Evidence map›Paper›PMID 37620042›Full record

Trial reportThe European respiratory journal2023

Tailored psychological intervention for anxiety or depression in COPD (TANDEM): a randomised controlled trial.

Stephanie J C Taylor, Ratna Sohanpal, Liz Steed, Karen Marshall, Claire Chan, Nahel Yaziji, Amy C Barradell, Paulino Font-Gilabert, Andrew Healey, Richard Hooper and 13 more

Open access · hybridAbstract readRandomized Controlled TrialMulticenter StudyPragmatic Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 2 countries.

Stephanie J C TaylorWolfson Institute of Population Health, Queen Mary University of London, London, UK s.j.c.taylor@qmul.ac.uk.
Ratna SohanpalWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Liz SteedWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Karen MarshallChest Clinic, RVI Hospital, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.ORCID 0000-0003-1902-3846
Claire ChanWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Nahel YazijiHealth Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Amy C BarradellNIHR Leicester Biomedical Research Centre - Respiratory, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK.
Paulino Font-GilabertHealth Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Andrew HealeyHealth Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Richard HooperWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Moira J KellyWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Kristie-Marie MammolitiWHO Collaborating Centre on Global Women's Health, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.ORCID 0000-0003-3614-7453
Stefan PriebeWolfson Institute of Population Health, Queen Mary University of London, London, UK.
Arvind RajasekaranDepartment of Respiratory Medicine, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
C Michael RobertsCentre for Digital Transformation of Health, University of Melbourne, Melbourne, Australia.
Vickie RowlandDepartment of Population Health, School of Life Course and Population Sciences, King's College London, London, UK.
Sally J SinghDepartment of Respiratory Sciences, Department of Health Sciences, University of Leicester, Leicester, UK.ORCID 0000-0002-9834-0366
Melanie SmukBlizard Institute, Queen Mary University of London, London, UK.
Martin UnderwoodWarwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Sarah WaseemWomen's Health Division, University College Hospital, London, UK.
Patrick WhiteDepartment of Population Health, School of Life Course and Population Sciences, King's College London, London, UK.
Vari WilemanHealth Psychology, School of Mental Health and Psychological Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hilary PinnockAllergy and Respiratory Research Group, Usher Institute, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5976-8386
Queen Mary University of London · GBKing's College London · GBBirmingham Women's Hospital · GBGlenfield Hospital · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBSandwell & West Birmingham Hospitals NHS Trust · GBThe University of Melbourne · AUUniversity College Hospital · GBUniversity Hospitals Coventry and Warwickshire NHS Trust · GBUniversity of Edinburgh · GBUniversity of Leicester · GB

Funding

Department of Health 13/146/02Wellcome Trust
6 · The paper itself

Abstract

backgroundThe TANDEM multicentre, pragmatic, randomised controlled trial evaluated whether a tailored psychological intervention based on a cognitive behavioural approach for people with COPD and symptoms of anxiety and/or depression improved anxiety or depression compared with usual care (control).

methodsPeople with COPD and moderate to very severe airways obstruction and Hospital Anxiety and Depression Scale subscale scores indicating mild to moderate anxiety (HADS-A) and/or depression (HADS-D) were randomised 1.25:1 (242 intervention and 181 control). Respiratory health professionals delivered the intervention face-to-face over 6-8 weeks. Co-primary outcomes were HADS-A and HADS-D measured 6 months post-randomisation. Secondary outcomes at 6 and 12 months included: HADS-A and HADS-D (12 months), Beck Depression Inventory II, Beck Anxiety Inventory, St George's Respiratory Questionnaire, social engagement, the EuroQol instrument five-level version (EQ-5D-5L), smoking status, completion of pulmonary rehabilitation, and health and social care resource use.

resultsThe intervention did not improve anxiety (HADS-A mean difference -0.60, 95% CI -1.40-0.21) or depression (HADS-D mean difference -0.66, 95% CI -1.39-0.07) at 6 months. The intervention did not improve any secondary outcomes at either time-point, nor did it influence completion of pulmonary rehabilitation or healthcare resource use. Deaths in the intervention arm (13/242; 5%) exceeded those in the control arm (3/181; 2%), but none were associated with the intervention. Health economic analysis found the intervention highly unlikely to be cost-effective.

conclusionThis trial has shown, beyond reasonable doubt, that this cognitive behavioural intervention delivered by trained and supervised respiratory health professionals does not improve psychological comorbidity in people with advanced COPD and depression or anxiety.

Indexed as

DepressionPulmonary Disease, Chronic ObstructiveAnxietyAnxiety DisordersHumansPsychosocial InterventionQuality of Life

Identifiers

PMID37620042
PMCPMC10620475
OpenAlexW4386135597

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.