ArticlePlant physiology2023
CALEOSIN 1 interaction with AUTOPHAGY-RELATED PROTEIN 8 facilitates lipid droplet microautophagy in seedlings.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- An active RNA transport mechanism into plant vacuoles.Nucleic acids research · 2026Article
- Lipid droplets at the interface of plant defense and pathogen exploitation.Frontiers in plant science · 2026Review
- From Model to Crop: Roles of Macroautophagy inGenes · 2025Review
- Characterization ofPlants (Basel, Switzerland) · 2025Article
- Overexpression of jojoba wax ester synthase in poplar increases foliar lipid accumulation, alters stomatal conductance, and increases water use efficiency.Plant biology (Stuttgart, Germany) · 2025Article
- Lipid Droplet Degradation Through Lipophagy in Aurantiochytrium limacinum mh0186.Marine biotechnology (New York, N.Y.) · 2025Article
- Identification and Characterization of Lipid Droplet-Associated Protein (LDAP) Isoforms from Tung Tree (Plants (Basel, Switzerland) · 2025Article
- Proteomics revealed novel functions and drought tolerance of Arabidopsis thaliana protein kinase ATG1.BMC biology · 2025Article
- Review
- Transcriptomic and proteomic analysis of oil body associated protein dynamics in the biofuel feedstock Pennycress (Frontiers in plant science · 2025Article
- Genomic Analysis of the Caleosin Family in Theaceae Reveals Lineagespecific Evolutionary Patterns.Current protein & peptide science · 2025Article
- Lipid droplets in plants: turnover and stress responses.Frontiers in plant science · 2025Review
- Exploiting lipid droplet metabolic pathway to foster lipid production: oleosin in focus.Plant cell reports · 2024Review
- Article
- α/β hydrolase domain-containing protein 1 acts as a lysolipid lipase and is involved in lipid droplet formation.National science review · 2024Article
- Autophagosome biogenesis and organelle homeostasis in plant cells.The Plant cell · 2024Review
- Genome-Wide Association Analysis Identifies Candidate Loci for Callus Induction in Rice (Plants (Basel, Switzerland) · 2024Article
- Lipid droplets are versatile organelles involved in plant development and plant response to environmental changes.Frontiers in plant science · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Lipid droplets (LDs) of seed tissues are storage organelles for triacylglycerols (TAGs) that provide the energy and carbon for seedling establishment. In the major route of LD degradation (lipolysis), TAGs are mobilized by lipases. However, LDs may also be degraded via lipophagy, a type of selective autophagy, which mediates LD delivery to vacuoles or lysosomes. The exact mechanisms of LD degradation and the mobilization of their content in plants remain unresolved. Here, we provide evidence that LDs are degraded via a process morphologically resembling microlipophagy in Arabidopsis (Arabidopsis thaliana) seedlings. We observed the entry and presence of LDs in the central vacuole as well as their breakdown. Moreover, we show co-localization of AUTOPHAGY-RELATED PROTEIN 8b (ATG8b) and LDs during seed germination and localization of lipidated ATG8 (ATG8-PE) to the LD fraction. We further demonstrate that structural LD proteins from the caleosin family, CALEOSIN 1 (CLO1), CALEOSIN 2 (CLO2), and CALEOSIN 3 (CLO3), interact with ATG8 proteins and possess putative ATG8-interacting motifs (AIMs). Deletion of the AIM localized directly before the proline knot disrupts the interaction of CLO1 with ATG8b, suggesting a possible role of this region in the interaction between these proteins. Collectively, we provide insights into LD degradation by microlipophagy in germinating seeds with a particular focus on the role of structural LD proteins in this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.