Evidence map›Paper›PMID 37619918›Full record

ArticleVirologica Sinica2023

Changing predominance of norovirus strains in children with acute gastroenteritis in Shanghai, 2018-2021.

Lijuan Lu, Yuanyun Ao, Ran Jia, Huaqing Zhong, Pengcheng Liu, Menghua Xu, Liyun Su, Lingfeng Cao, Jin Xu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virologica Sinica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lijuan LuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Yuanyun AoDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Ran JiaDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Huaqing ZhongDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Pengcheng LiuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Menghua XuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Liyun SuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Lingfeng CaoDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China.
Jin XuDepartment of Clinical Laboratory, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201100, China; Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 201100, China. Electronic address: jinxu_125@163.com.
Children's Hospital of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Norovirus (NoV) is a major pathogen that causes acute gastroenteritis (AGE) in people of all ages, especially in children. In this study, we investigated the molecular epidemiological characteristics of NoV in children with AGE in Shanghai from 2018 to 2021. The overall detection rate of NoV was 11.9% (181/1545), with annual detection rates of 9.4% (36/381), 13.6% (29/213), 5.8% (13/226) and 14.2% (103/725), respectively. Of note, the prevalence of NoV in 2020 was significantly lower than that in 2018-2019 (10.9%, 65/594) (P ​= ​0.023) and 2021 (14.2%, 103/725) (P ​= ​0.000). The 181 NoV strains identified in this study were classified into the GI group (1.1%, 2/181), GII group (98.3%, 178/181) and GIX group (0.6%, 1/181) according to the VP1 gene. The most common NoV VP1 genotype was GII.4 Sydney_2012 (63.5%, 115/181), followed by GII.3 (19.9%, 36/181) and GII.2 (9.4%, 17/181). For P genotypes, 174 strains were sequenced successfully according to the RdRp gene, and the predominant genotype was GII.P16 (44.8%, 78/174), followed by GII.P31 (25.9%, 45/174) and GII.P12 (21.3%, 37/174). Among the 174 cases, GII.4 Sydney_2012[P16] (36.8%, 64/174) was the dominant genotype, followed by GII.4 Sydney_2012[P31] (25.3%, 44/174), GII.3[P12] (20.1%, 35/174) and GII.2[P16] (8.0%, 14/174). In particular, the dominant genotypes in Shanghai changed from GII.4 Sydney_2012[P31] in 2018-2019 to GII.4 Sydney_2012[P16] in 2020-2021. This is the first report to describe the epidemiological changes in NoV infection before and during the COVID-19 pandemic in Shanghai. These data highlight the importance of continuous surveillance for NoV in children with AGE in Shanghai.

Indexed as

Caliciviridae InfectionsGastroenteritisNorovirusChildChinaFecesGenotypeHumansPandemicsPhylogenyAcute gastroenteritisChildrenGenotypeNorovirus (NoV)Recombination

Identifiers

PMID37619918
PMCPMC10590699
OpenAlexW4386067430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.