Evidence map›Paper›PMID 37615834›Full record

ArticleDermatology and therapy2023

History of S. aureus Skin Infection Significantly Associates with History of Eczema Herpeticum in Patients with Atopic Dermatitis.

Mary C Moran, Alanna Klose, Takeshi Yoshida, Anna De Benedetto, Lynda C Schneider, Peck Y Ong, Eric L Simpson, Donald Y M Leung, Benjamin L Miller, Christopher L Seplaki and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dermatology and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Mary C MoranDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-6456-082X
Alanna KloseDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0009-0009-6967-3581
Takeshi YoshidaDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0003-0133-5067
Anna De BenedettoDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-6293-435X
Lynda C SchneiderDivision of Allergy-Immunology, Department of Pediatrics, Boston Children's Hospital-Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5633-0178
Peck Y OngDivision of Clinical Immunology and Allergy, Children's Hospital Los Angeles-University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6664-463X
Eric L SimpsonDepartment of Dermatology, Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-0853-0252
Donald Y M LeungDivision of Allergy-Immunology, Department of Pediatrics, National Jewish Health-University of Colorado School of Medicine, Denver, CO, USA.ORCID http://orcid.org/0000-0002-0177-3844
Benjamin L MillerDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-9168-8047
Christopher L SeplakiDepartment of Public Health Sciences, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-8296-7714
Lisa A BeckDepartment of Dermatology, University of Rochester Medical Center, Rochester, NY, USA. lisa_beck@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-8452-667X
University of Rochester Medical Center · USBoston Children's Hospital · USNational Jewish Health · USOregon Health & Science University · USUniversity of Southern California · US

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Experimental and Computational Analysis of the Human Epidemiology and Response to SARS-CoV-2 (HEROS) CohortUM1AI151958 · NIAID · NATIONAL JEWISH HEALTH · PI Donald YM Leung · 2020 to 2026
$38.3M
Targeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI GEHA, RAIF SALIM · 2015 to 2019
$30.6M
The T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6M
Biomarker Identification, Viral Susceptibility and Management in S. aureus Colonized AD PatientsU01AI152011 · NIAID · UNIVERSITY OF ROCHESTER · PI Lisa Ann Beck · 2020 to 2026
$3.2M
NCATS NIH HHS UL1 TR002369NCATS NIH HHS UL1TR002369NIAID NIH HHS HHSN272201000017CNIAID NIH HHS T32 AI007285NIAID NIH HHS U01 AI152011NIAID NIH HHS U19 AI117673NIAID NIH HHS UM1 AI151958
6 · The paper itself

Abstract

introductionPatients with atopic dermatitis (AD) are uniquely susceptible to a number of serious viral skin complications, including eczema herpeticum (EH), caused by herpes simplex virus. This study explored the associations between biomarkers of epithelial barrier dysfunction, type 2 immunity, Staphylococcus aureus infection, and S. aureus-specific immunoglobulin responses in a cohort of AD subjects with and without a history of EH (EH+ and EH-, respectively).

methodsA total of 112 subjects with AD (56 EH+, 56 EH-), matched by age and AD severity, were selected from a registry of over 3000 AD subjects. Logistic regression was used to test the association between history of S. aureus skin infection and history of EH, while controlling for a number of confounders.

resultsCompared to those without a history of S. aureus skin infection, subjects with a history of S. aureus skin infection were found to have more than sixfold increased odds of having a history of EH (6.60, 95% confidence interval [CI]: 2.00-21.83), after adjusting for history of other viral skin infections (molluscum contagiosum virus, human papillomavirus), serum total IgE, and IgG against the S. aureus virulence factor SElX.

conclusionsThese findings indicate an important relationship between S. aureus skin infections and EH.

Indexed as

Atopic dermatitisEczema herpeticumImmunoglobulinsS. aureusViral skin infections

Identifiers

PMID37615834
PMCPMC10539263
OpenAlexW4386117266

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.