Evidence map›Paper›PMID 37615806›Full record

ArticleEuropean geriatric medicine2023

Association between dietary vitamin E intake and cognitive decline among old American: National Health and Nutrition Examination Survey.

Kai Zhang, Yu Han, Zhaoxuan Gu, Zhengyan Hou, Xiaoqi Yu, Min Gao, Tianyi Cai, Yafang Gao, Jinyu Xie, Fangming Gu and 3 more

Abstract read
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In one paragraph

Article in European geriatric medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kai ZhangThe Second Hospital, Jilin University, No. 218, Ziqiang Street, Changchun, Jilin, China. zhangkai7018@mails.jlu.edu.cn.ORCID 0000-0002-4069-6319
Yu HanDepartment of Ophthalmology, First Hospital of Jilin University, No.71 Xinmin Street, Changchun, Jilin, China.
Zhaoxuan GuThe Second Hospital, Jilin University, No. 218, Ziqiang Street, Changchun, Jilin, China.
Zhengyan HouBethune Second School of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Xiaoqi YuBethune Second School of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Min GaoBethune Second School of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Tianyi CaiBethune Second School of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Yafang GaoBethune Second School of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Jinyu XieBethune Second School of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Fangming GuBethune Second School of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Jianguo ChenBethune First College of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Bowen ChenBethune First College of Clinical Medicine, Jilin University, No.828 Xinmin Street, Changchun, Jilin, China.
Tianzhou LiuDepartment of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital, Jilin University, No. 218, Ziqiang Street, Changchun, Jilin, China. liutianzhou@jlu.edu.cn.
Jilin University · CNSecond Affiliated Hospital of Jilin University · CNFirst Bethune Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNumerous studies have reported that vitamin E plays a key role in nervous system development and neurotransmitter production. This study aimed to investigate changes in vitamin E intake in older adults with low cognitive performance using NHANES.

methodsIn this cross-sectional study, we examined a sample of 2255 American adults aged 60 and over between 2011 and 2014. We collected dietary data by averaging two recalls for dietary use to determine vitamin E intake. We assessed cognitive function using five tests and analyzed the association between these variables using a multivariate logistic regression model.

resultsA total of 2255 participants aged ≥ 60 years from the National Health and Nutrition Examination Survey (NHANES) for the 2011-2014 cycle were included in the analysis. Vitamin E intake was negatively associated with cognitive function. In the Z test, with each 1 mg/day increase in dietary intake of vitamin E, there was a 6% decrease in the correlation with cognitive impairment (OR = 0.94, 95% CI 0.91-0.97) in the fully fitted model (OR = 0.94, 95% CI 0.91-0.97). These findings remained consistent when analyzing the exposure as a categorical variable. In comparison to Q1, Q4 showed a 53% reduction in the incidence of cognitive impairment in the Z test (OR = 0.47, 95% CI 0.33-0.67).No significant statistical interaction between the variables was found.

conclusionAn increased dietary intake of vitamin E has been associated with decreased cognitive impairment in individuals over 60 years old. The dose-response curve showed an L-shaped association between dietary vitamin E intake and cognitive decline in US adults, with an inflection point of approximately 9.296 mg/day.

Indexed as

CognitionCognitive DysfunctionDietVitamin EAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesVitamin EAssociationCognitionGeneralized additive modelSubgroup analysisVitamin E intake

Identifiers

PMID37615806
OpenAlexW4386116780

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.