Evidence map›Paper›PMID 37615624›Full record

ArticleNano letters2023

Nanoclay Drug-Delivery System Loading Potassium Iodide Promotes Endocytosis and Targeted Therapy in Anaplastic Thyroid Cancer.

Peng Huang, Neng Tang, Lin-Feng Mao, Yi Zhang, Xiao-Feng Tang, Ruo-Yun Zhou, Bo Wei, Hai-Long Tan, Qi-Man Shi, Jing Lin and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Peng HuangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.ORCID 0000-0003-3011-3359
Neng TangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Lin-Feng MaoDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province 530021, China.
Yi ZhangCentre for Mineral Materials, School of Minerals Processing and Bioengineering, Central South University, Changsha, Hunan Province 410083, China.ORCID 0000-0002-4623-4203
Xiao-Feng TangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Ruo-Yun ZhouDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Bo WeiDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Hai-Long TanDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Qi-Man ShiDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Jing LinDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Zhe-Cheng LiDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Shi ChangDepartment of General Surgery, Xiangya Hospital Central South University, Changsha, Hunan Province 410008, China.
Central South University · CNGuangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid proliferative biological behavior of primary foci of anaplastic thyroid cancer (ATC) makes it a lethal tumor. According to the specific iodine uptake capacity of thyroid cells and enhanced endocytosis of ATC cells, we designed a kind of nanoclay drug-loading system and showed a promising treatment strategy for ATC. Introducing potassium iodide (KI) improves the homoaggregation of clay nanoparticles and then affects the distribution of nanoparticles in vivo, which makes KI@DOX-Kaolin

Indexed as

Thyroid Carcinoma, AnaplasticThyroid NeoplasmsDrug Delivery SystemsEndocytosisHumansKaolinPotassium IodideKaolinPotassium Iodideanaplastic thyroid cancerendocytosishomoaggregationnanovesiclestargeted drug delivery

Identifiers

PMID37615624
PMCPMC10510574
OpenAlexW4386116685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.