Evidence map›Paper›PMID 37615301›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2023

Relationship between default mode network and resting-state electroencephalographic alpha rhythms in cognitively unimpaired seniors and patients with dementia due to Alzheimer's disease.

Claudio Babiloni, Susanna Lopez, Giuseppe Noce, Raffaele Ferri, Simonetta Panerai, Valentina Catania, Andrea Soricelli, Marco Salvatore, Flavio Nobili, Dario Arnaldi and 25 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 16 institutions in 8 countries.

Claudio BabiloniDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Susanna LopezDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Giuseppe NoceIRCCS Synlab SDN, Naples, Italy.
Raffaele FerriOasi Research Institute - IRCCS, Troina, Italy.
Simonetta PaneraiOasi Research Institute - IRCCS, Troina, Italy.
Valentina CataniaOasi Research Institute - IRCCS, Troina, Italy.
Andrea SoricelliIRCCS Synlab SDN, Naples, Italy.
Marco SalvatoreIRCCS Synlab SDN, Naples, Italy.
Flavio NobiliClinica neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Dario ArnaldiClinica neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Francesco FamàClinica neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Federico MassaClinica neurologica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Carla ButtinelliDepartment of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Franco GiubileiDepartment of Neuroscience, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Fabrizio StocchiIRCCS San Raffaele, Rome, Italy.
Laura VaccaIRCCS San Raffaele, Rome, Italy.
Moira MarizzoniLaboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Fabrizia D'AntonioDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Giuseppe BrunoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Carlo De LenaDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Bahar GüntekinDepartment of Biophysics, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Ebru YıldırımProgram of Electroneurophysiology, Vocational School, Istanbul Medipol University, Istanbul, Turkey.ORCID 0000-0002-7715-3035
Lutfu HanoğluDepartment of Neurology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
Görsev YenerIzmir School of Economics, Faculty of Medicine, Izmir, Turkey.
Deniz YerlikayaHealth Sciences Institute, Department of Neurosciences, Dokuz Eylül University, Izmir, Turkey.
John Paul TaylorTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom.
Julia SchumacherTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom.
Ian McKeithTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, United Kingdom.
Laura BonanniDepartment of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
Patrizia PantanoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Claudia PiervincenziDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Nikolaos PetsasScuola di Specializzazione in Statistica Medica e Biometria, Dipartimento di Sanità Pubblica e Malattie Infettive, Sapienza University of Rome, Rome, Italy.
Giovanni B FrisoniLaboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Claudio Del PercioDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Filippo CarducciDepartment of Physiology and Pharmacology "Vittorio Erspamer," Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITOspedale Policlinico San Martino · ITIstanbul Medipol University · TROasi Maria SS · ITOspedale Civile di Vittorio Veneto · ITSynlab Czech (Czechia) · CZIRCCS Ospedale San Raffaele · ITNewcastle University · GBCentro San Giovanni di Dio Fatebenefratelli · ITGerman Center for Neurodegenerative Diseases · DEIstituto Neurologico Mediterraneo · ITİzmir University of Economics · TRNeurosciences Institute · USUniversità degli studi di Cassino e del Lazio Meridionale · ITUniversity of Chieti-Pescara · ITUniversity of Geneva · CH

Funding

IRCCS San Raffaele Pisana of RomeItalian Ministry of HealthUnit of Sapienza University of Rome GAP-101058516
6 · The paper itself

Abstract

Here we tested the hypothesis of a relationship between the cortical default mode network (DMN) structural integrity and the resting-state electroencephalographic (rsEEG) rhythms in patients with Alzheimer's disease with dementia (ADD). Clinical and instrumental datasets in 45 ADD patients and 40 normal elderly (Nold) persons originated from the PDWAVES Consortium (www.pdwaves.eu). Individual rsEEG delta, theta, alpha, and fixed beta and gamma bands were considered. Freeware platforms served to derive (1) the (gray matter) volume of the DMN, dorsal attention (DAN), and sensorimotor (SMN) cortical networks and (2) the rsEEG cortical eLORETA source activities. We found a significant positive association between the DMN gray matter volume, the rsEEG alpha source activity estimated in the posterior DMN nodes (parietal and posterior cingulate cortex), and the global cognitive status in the Nold and ADD participants. Compared with the Nold, the ADD group showed lower DMN gray matter, lower rsEEG alpha source activity in those nodes, and lower global cognitive status. This effect was not observed in the DAN and SMN. These results suggest that the DMN structural integrity and the rsEEG alpha source activities in the DMN posterior hubs may be related and predict the global cognitive status in ADD and Nold persons.

Indexed as

Alpha RhythmAlzheimer DiseaseBrainCognitionDefault Mode NetworkAgedAged, 80 and overElectroencephalographyFemaleGray MatterHumansMagnetic Resonance ImagingMaleRestAlzheimer’s disease with dementia (ADD)Default mode network (DMN)Exact low-resolution brain electromagnetic source tomography (eLORETA)Resting state electroencephalographic (rsEEG) alpha rhythmsStructural magnetic resonance imaging (sMRI)

Identifiers

PMID37615301
PMCPMC10588004
OpenAlexW4386115991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.