Evidence map›Paper›PMID 37614972›Full record

ArticleFrontiers in neurology2023

Lacunes are associated with late-stage multiple sclerosis comorbidities.

Lijie Zhang, Xintong Yu, Yexiang Zheng, Aiyu Lin, Zaiqiang Zhang, Shaowu Li, Ning Wang, Ying Fu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lijie ZhangDepartment of Neurology and Institute of Neurology of The First Affiliated Hospital, Institute of Neuroscience, Fuzhou, China.
Xintong YuDepartment of Neurology and Institute of Neurology of The First Affiliated Hospital, Institute of Neuroscience, Fuzhou, China.
Yexiang ZhengDepartment of Neurology and Institute of Neurology of The First Affiliated Hospital, Institute of Neuroscience, Fuzhou, China.
Aiyu LinDepartment of Neurology and Institute of Neurology of The First Affiliated Hospital, Institute of Neuroscience, Fuzhou, China.
Zaiqiang ZhangDepartment of Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Shaowu LiDepartment of Neuroimaging, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ning WangDepartment of Neurology and Institute of Neurology of The First Affiliated Hospital, Institute of Neuroscience, Fuzhou, China.
Ying FuDepartment of Neurology and Institute of Neurology of The First Affiliated Hospital, Institute of Neuroscience, Fuzhou, China.
Fujian Medical University · CNCapital Medical University · CNBeijing Institute of Neurosurgery · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a condition that affects the veins and small blood vessels. Previous research suggests that individuals with MS have an increased risk of vascular events and higher mortality rates. However, the relationship between MS and cerebral small vessel disease (CSVD) remains uncertain. This study aims to investigate the association between MS and lacunes. A prospective observational study was conducted, including a total of 112 participants, of which 46 had MS and 66 had CSVD. All participants underwent an MRI scan and a battery of neurological functional assessments. The presence of definite lacunes and black holes was determined through the analysis of T2-weighted, T1-weighted, and FLAIR images. The occurrence of lacunes in MS patients was found to be 19.6%. Notably, the duration of MS was identified as the sole risk factor for the development of lacune lesions in MS patients [odds ratio (OR) = 1.3, 95% confidence interval (CI) = 1.1-1.6,

Indexed as

arteriolar damagecerebral small vessel disease (CSVD)disease durationlacunemultiple sclerosis (MS)

Identifiers

PMID37614972
PMCPMC10442480
OpenAlexW4385660885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.