ArticleFrontiers in pediatrics2023
Severe gastrointestinal involvement in pediatric IgA vasculitis: a retrospective single-center cohort study in China.
Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 18 citations in OpenAlex.
- Development and validation of a clinical prediction model for gastrointestinal hemorrhage in pediatric IgA vasculitis.BMC pediatrics · 2026Observational
- Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort.Journal of pediatric gastroenterology and nutrition · 2026Article
- Predictive value of neutrophil-to-lymphocyte ratio and fibrinogen degradation products for renal involvement in pediatric immunoglobulin A vasculitis.Translational pediatrics · 2026Article
- Factors predicting the severity of gastrointestinal involvement in children with IgA vasculitis? A Turkish multicenter cohort study.European journal of pediatrics · 2026Article
- Article
- Demographic, Clinical, and Laboratory Characteristics of Pediatric IgA Vasculitis: A Retrospective Five-Year Single-Center Experience.Journal of clinical medicine · 2026Article
- Recurrent immunoglobulin A vasculitis in children and adolescents: prevalence and associated risk factors.Clinical and experimental pediatrics · 2026Article
- Article
- Mucosal Fibrosis on Biopsy Predicting Intestinal Perforation in Adult-Onset IgA Vasculitis: A Case Report.Cureus · 2025Article
- Clinical features and risk factors of abdominal IgA vasculitis in adults.Clinical rheumatology · 2025Article
- Immunoglobulin a vasculitis with central nervous system involvement: analysis of 10 cases.Clinical and experimental medicine · 2025Article
- Gastrointestinal features of pediatric iga vasculitis and their association with renal complications: an observational study.European journal of pediatrics · 2025Observational
- Risk factors for gastrointestinal bleeding in children with Henoch-Schönlein purpura.Frontiers in pediatrics · 2025Article
- Risk prediction for gastrointestinal bleeding in pediatric Henoch-Schönlein purpura using an interpretable transformer model.Frontiers in physiology · 2025Article
- Clinical review of adult Henoch-Schönlein purpura and analysis of predictors related to gastrointestinal involvement.Frontiers in immunology · 2025Article
- Characteristics of cutaneous manifestations in immunoglobulin a vasculitis and their relationships with system involvement and treatment needs.European journal of pediatrics · 2024Observational
- Predictors of Gastrointestinal Involvement in Children with IgA Vasculitis: Results from a Single-Center Cohort Observational Study.Children (Basel, Switzerland) · 2024Article
- Exploration of the pathogenesis of nephrotic syndrome and traditional Chinese medicine intervention based on gut microbiota.Frontiers in immunology · 2024Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The study aimed to describe the characteristics of gastrointestinal (GI) involvement in a cohort of hospitalized children with IgA vasculitis (IgAV) in China. Method: We reviewed the records of hospitalized IgAV patients from January 2014 to December 2020 at one tertiary medical center. The patients were divided into the severe GI group and the non-severe GI group according to the presence of massive GI bleeding and complications. The clinical manifestations, laboratory factors, and treatment were analyzed between the two groups. Results: A total of 1,179 patients were hospitalized due to IgAV. GI involvement was noted in 50% (589) of the patients, of whom 288 (48.9%) had severe GI involvement. GI complications were observed in 34 patients with IgAV with GI involvement. Rare onset age (<3 years or within 13-17 years), purpura above the waist, vomiting, high neutrophil-to-lymphocyte ratio, and decreased serum albumin were factors associated with severe GI involvement. Frequencies of renal involvement and biopsy-proven nephritis were higher in the severe GI group. The most commonly used medications were corticosteroids (100.0%) in the severe GI group. The maximum corticosteroid dose was higher (2.9 vs. 2.0 mg/kg), and more second-line therapies were needed (30.9% vs. 16.94%) in the severe GI group. Conclusions: Severe GI involvement in children is common in our center. Rare onset age, purpura above the waist, vomiting, high neutrophil-to-lymphocyte ratio, and decreased serum albumin are associated with severe GI involvement. Patients with severe GI involvement need higher doses of corticosteroids and second-line therapy.
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