Updated meta-analysis of randomized controlled trials on primary outpatient thromboprophylaxis in patients with gastric and gastroesophageal junction cancers receiving chemotherapy.

Kyaw Zin Thein, Thura Win Htut, Yin Mon Myat, Myat Min Han, Myint Aung Win, Ei Moe Phyu, Thein Hlaing Oo

Abstract read

In one paragraph

Article in Proceedings (Baylor University. Medical Center), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Kyaw Zin TheinDivision of Hematology and Medical Oncology, Oregon Health and Science University/Knight Cancer Institute, Portland, Oregon, USA.ORCID https://orcid.org/0000-0003-1518-1097

Thura Win HtutDepartment of Hematology, Aberdeen Royal Infirmary, University of Aberdeen, NHS Grampian, Scotland, UK.ORCID https://orcid.org/0000-0002-5508-1472

Yin Mon MyatUniversity College Dublin, Dublin, Ireland.

Myat Min HanDepartment of Internal Medicine, Interfaith Medical Center, Brooklyn, New York, USA.

Myint Aung WinDepartment of Internal Medicine, Lewis Gale Medical Center, Salem, Virginia, USA.

Ei Moe PhyuDepartment of Hospital Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

Thein Hlaing OoSection of Benign Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-5201-731X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced gastric cancer is a highly thrombogenic cancer per Khorana score. Recent clinical practice guidelines suggest primary outpatient thromboprophylaxis (POTP) for patients with a Khorana score ≥2. We performed an updated meta-analysis to evaluate the benefit of POTP in patients with gastric cancer and gastroesophageal junction cancers receiving chemotherapy. Randomized controlled trials with reduction in venous thromboembolism (VTE) as a primary or secondary endpoint were incorporated. A total of 631 patients from subgroups of three randomized controlled trials were included. The VTE incidence was 1.6% and 5.1% in POTP and control groups, respectively (risk ratio 0.31; confidence interval 0.11 to 0.83;

Indexed as

Gastric cancergastro-esophageal junction cancermeta-analysisprimary outpatient thromboprophylaxisvenous thromboembolism

Identifiers

PMID37614866

DOI10.1080/08998280.2023.2225913

PMCPMC10443955

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.