ArticleInfection and drug resistance2023
Correlation of Coagulation Dysfunction with Infection and Hypercapnia in Acute Exacerbation of COPD Patients.
Article in Infection and drug resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Association between sarcopenia and hypercoagulability in elderly patients with chronic obstructive pulmonary disease.European geriatric medicine · 2026Article
- An Interpretable AdaBoost Model for 1-Year Readmission Risk Prediction in AECOPD Patients with Hypertension.International journal of chronic obstructive pulmonary disease · 2026Article
- The impact of spontaneous ventilation anesthesia on thrombosis risk for thoracic surgery: a beagle dog model study.BMC anesthesiology · 2025Article
- Predicting Superaverage Length of Stay in COPD Patients with Hypercapnic Respiratory Failure Using Machine Learning.Journal of inflammation research · 2025Article
- Thrombin generation indices and Wells score predict pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease.Clinics (Sao Paulo, Brazil) · 2025Article
- Prognostic Value of Biomarkers in Chronic Obstructive Pulmonary Disease: A Comprehensive Review.International journal of chronic obstructive pulmonary disease · 2025Review
- Predictors for acute exacerbation of interstitial pneumonia following lung cancer surgery: a multicenter study.BMC pulmonary medicine · 2024Article
- A Diagnostic Nomogram for Predicting Hypercapnic Respiratory Failure in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2024Article
- Elevated Tissue Factor and TFPI Levels in Acute COPD Exacerbations: A Prospective Comparison With Stable COPD and Healthy Controls.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This study aims to explore the factors influencing the coagulation function of patients with chronic obstructive pulmonary disease (COPD) and its effects on thrombosis. Methods: A total of 155 COPD patients, including 118 patients with acute exacerbation of COPD (AECOPD) and 37 patients with stable COPD (SCOPD), were enrolled in this study. Meanwhile, 50 patients with gastrointestinal polyps found during physical examination and treated with surgery in the same period were enrolled as the control group. The basic data, routine blood tests, C-reactive protein (CRP), procalcitonin (PCT), and coagulation indexes of the three groups were collected, as well as arterial blood gas indexes of AECOPD patients. Results: The differences in erythrocyte count and hemoglobin among groups were not statistically significant. Compared with the SCOPD group and control group, white blood cell (WBC), neutrophil percentage, PCT, CRP, prothrombin time (PT), and fibrinogen (FIB) in the AECOPD group increased significantly, while the international normalized ratio (INR) decreased (P < 0.05). The differences in activated partial thromboplastin time (APTT) and D-dimer among groups were not statistically significant (P > 0.05). Thrombin time (TT) in the AECOPD group was shorter than that of the control group, and PT was longer than that of the SCOPD group (P < 0.05). Five patients with AECOPD and one patient with SCOPD had venous thrombosis. Conclusion: The abnormal coagulation function in AECOPD patients is related to the degree of infection and hypercapnia, which may be a risk factor for thrombosis.
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