Evidence map›Paper›PMID 37614346›Full record

ArticleThe Lancet regional health. Southeast Asia2023

High PrEP uptake, adherence, persistence and effectiveness outcomes among young Thai men and transgender women who sell sex in Bangkok and Pattaya, Thailand: findings from the open-label combination HIV prevention effectiveness (COPE) study.

Brian W Weir, Andrea L Wirtz, Tareerat Chemnasiri, Stefan D Baral, Michele Decker, Chen Dun, Sandra Hsu Hnin Mon, Chaiwat Ungsedhapand, Eileen F Dunne, Joseph Woodring and 21 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet regional health. Southeast Asia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 5 institutions in 2 countries.

Brian W WeirCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Andrea L WirtzCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Tareerat ChemnasiriDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Stefan D BaralCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Michele DeckerCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Chen DunCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Sandra Hsu Hnin MonCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Chaiwat UngsedhapandDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Eileen F DunneDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Joseph WoodringDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Sarika PattanasinDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Wichuda SukwichaDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Michael C ThigpenDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Anchalee VarangratDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Anchalee WarapornmongkholkulDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Siobhan O'ConnorDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Julie P NgoCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Noor QaragholiCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Haley I SiselCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jasmine M TruongCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Surang JanyamService Workers in Group Foundation (SWING), Bangkok and Pattaya, Thailand.
Danai LinjongratRainbow Sky Association of Thailand (RSAT), Bangkok, Thailand.
Somchai SriplienchanService Workers in Group Foundation (SWING), Bangkok and Pattaya, Thailand.
Pachara SirivongrangsonDivision of HIV Prevention, Thailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.
James F RooneyMedical Affairs, Gilead Sciences, Foster City, CA, USA.
Patrick SullivanDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Boosbun Chua-IntraDivision of HIV Prevention, Thailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.
Andrew C HickeyDivision of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Chris BeyrerCenter for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
COPE Study Teamabcdefghijklmn
COPE Study Team
Centers for Disease Control and Prevention · USJohns Hopkins University · USMinistry of Public Health · THEmory University · USGilead Sciences (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Daily oral pre-exposure prophylaxis (PrEP) is effective in preventing HIV infection, but no study has evaluated combination prevention interventions with PrEP for transgender women (TGW) and men who have sex with men (MSM) who sell sex. Methods: The Combination Prevention Effectiveness (COPE) study was a community-based, non-randomized implementation study in Bangkok and Pattaya, Thailand. Participants were HIV-negative MSM and TGW aged 18-26 years who reported exchanging sex with men in the prior 12 months and who met 2014 U.S. Public Health Service PrEP eligibility criteria. The intervention included quarterly HIV testing, semiannual testing for sexually transmitted infections, provision of condoms with lubricant, and the opportunity to initiate or end daily oral PrEP use at any time during study participation. Participants taking PrEP received monthly adherence counseling and short message service reminders. The primary outcome was HIV incidence rate ratio (IRR) on PrEP vs. not on PrEP. Secondary outcomes were PrEP initiation, PrEP use at 12 months, and PrEP adherence. Findings: From October 2017 to August 2019, 846 participants were enrolled: 531 (62.8%) immediately initiated PrEP; 104 (12.3%) subsequently initiated PrEP, and 211 (24.9%) never initiated PrEP. Among those initiating PrEP within 30 days of enrollment; 85.9% were on PrEP at the 12-months. When taking PrEP, participants reported adherent PrEP use at 94.2% of quarterly assessments. Ten HIV seroconversions occurred without PrEP use (incidence rate [IR] = 3.42 per 100 person-years [PY]; 95% CI = 1.64-6.30), while zero cases occurred with PrEP use (IR = 0.0 per 100PY; 95% CI = 0.0-0.62), with IRR = 0.0 (95% CI = 0.0-0.22; p < 0.001). Interpretation: Young Thai MSM and TGW who exchange sex can have high PrEP uptake, persistence and adherence, and low HIV incidence when offered in supportive community-based settings. Funding: U.S. National Institute of Allergy and Infectious Diseases; Centers for Disease Control and Prevention.

Indexed as

HIVMen who have sex with menPre-exposure prophylaxisPreventionSex workThailandTransgender persons

Identifiers

PMID37614346
PMCPMC10442968
OpenAlexW4378221711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.