ReviewCureus2023
A Review of the Current Literature on Pleomorphic Adenoma.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Metastatic Pleomorphic Adenoma: A Systematic Review.Head and neck pathology · 2025Pooled it
- A case report of pleomorphic adenoma in a 27-year-old female.Radiology case reports · 2026Article
- Pleomorphic Adenomas and Their Atypical Morphology: Pitfalls in the Diagnosis of Salivary Gland Tumors.Diagnostics (Basel, Switzerland) · 2026Review
- The paradox of benign histology and malignant behavior: lymphatic metastasis in pleomorphic adenoma-a case report.Journal of medical case reports · 2026Article
- Synchronous mucoepidermoid carcinoma of sublingual gland and pleomorphic adenoma of palatal gland-a case report and literature review.BMC oral health · 2026Review
- Giant Pleomorphic Adenoma of the Hard Palate in a 17-Year-Old Afghan Male.International medical case reports journal · 2026Article
- Breast mass imaging identification of rare pleomorphic adenoma after follow-up of gastric cancer surgery: a case report.Frontiers in oncology · 2026Article
- [Pediatric salivary pleomorphic adenoma: report of 30 cases].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025Article
- Pleomorphic Adenoma in the Setting of Triple-Negative Breast Cancer: A Case Report.Clinical case reports · 2025Article
- Article
- Recurrence of Pleomorphic Adenoma in the Submandibular Gland: A Case Report and Literature ReviewCurrent medical imaging · 2025Review
- Article
- Decoding a Rare Case of Pleomorphic Adenoma: A Case Report and Review of the Literature.Cureus · 2024Article
- Unique Cytopathological Findings of a Mucinous Myoepithelioma Showing a Mucous Globule and a "Sieve-Like" Structure.Cureus · 2024Article
- Pleomorphic Adenoma of the Nasal Cavity.Cureus · 2024Article
- Pediatric Sinonasal Pleomorphic Adenoma: A Case Report.Journal of rhinology : official journal of the Korean Rhinologic Society · 2024Article
- Keratinizing Pleomorphic Adenoma of the Buccal Mucosa: A Comprehensive Clinical and Histopathological Analysis of a Rare Case.Ethiopian journal of health sciences · 2024Article
- Case Series: Pleomorphic adenoma in minor salivary gland.F1000Research · 2024Article
- Extracapsular dissection via single cervical incision for parotid pleomorphic adenoma.Clinical oral investigations · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pleomorphic adenomas (PA) are the most common benign salivary gland tumors. They arise from the major salivary glands, as well as the minor salivary glands. They may arise rarely from the palate, oral cavity, neck, and nasal cavity also. Yet, the fourth, fifth, and sixth decades of life are the most common for them to manifest. Forty percent of them occur in males and 60% in females. It is a benign mixed tumor, which has three components: an epithelial component, a myoepithelial cell component, and a mesenchymal component. A fibrous capsule separates these cells from the surrounding tissues. It generally presents as a slowly progressing painless swelling, which is well-delineated, nonsymptomatic, and not involving the facial nerve. Salivary gland tumors can be accurately diagnosed before surgery using fine-needle aspiration (FNA), ultrasonography (USG), and computed tomography (CT) scan. Calponin, cluster of differentiation 9 (CD9), glial fibrillary acidic protein (GFAP), Mcl-2, metastasis suppressor gene (NM23), p63, S-100, smooth muscle actin (SMA), and SRY-box transcription factor 10 (SOX10) exhibit the majority of the positive reactions in pleomorphic adenomas. The diagnostic marker pleomorphic adenoma gene 1 (PLAG1) is frequently employed since it is specific for pleomorphic adenoma. Although benign, these epithelial tumors have a propensity to recur and undergo malignant transformation if incompletely excised, leading to increased morbidity in these patients. A review of the consensus guidelines and literature was conducted, and the online literature on the subject from 2002 was included. This article is not a complete review of all the available literature; rather, it is a comprehensive review of the topic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.