ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Successful cognitive aging is associated with thicker anterior cingulate cortex and lower tau deposition compared to typical aging.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- What characterizes the exceptional cognition of superagers? A systematic review of multidomain biomarkers of successful cognitive aging.The Gerontologist · 2026Pooled it
- Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span.Neurobiology of aging · 2026Article
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- HIF-2α Depletion and HIF-1α Overexpression in Vulnerable Brain Regions Distinguish Alzheimer's Disease with Cerebral Amyloid Angiopathy.International journal of molecular sciences · 2026Article
- Whole-brain cholinergic modulation following computerized cognitive training in healthy older adults: a [18F]FEOBV PET study.GeroScience · 2026Article
- A physically and mentally active lifestyle relates to younger brain and cognitive age.GeroScience · 2026Article
- Structural and functional alterations of posterior cingulate cortex subregions in successful cognitive aging.Frontiers in aging neuroscience · 2026Article
- Alterations in functional connectivity of the anterior cingulate cortex associated with different levels of tau and amyloid-Frontiers in neuroscience · 2026Article
- Subtype-Specific Brain Atrophy and White Matter Alterations in Mild Cognitive Impairment.Brain sciences · 2025Article
- Exploring Centiloid Robustness: Impact of Sample Size and Image Resolution on Centiloid Conversion Accuracy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
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- The first 25 years of the Northwestern University SuperAging Program.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association of a Brief Computerized Cognitive Assessment With Cholinergic Neurotransmission: Assessment Validation Study.JMIR formative research · 2025Article
- Understanding the cognitive factors which contribute to individual differences in financial capacity in aging.Scientific reports · 2025Article
- [Biomolecules · 2025Article
- Distinct patterns of cognitive traits in extreme old age and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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- Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade.Nature communications · 2024Article
- The Impact of HIV on Early Brain Aging-A Pathophysiological (Re)View.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionThere is no consensus on either the definition of successful cognitive aging (SA) or the underlying neural mechanisms.
methodsWe examined the agreement between new and existing definitions using: (1) a novel measure, the cognitive age gap (SA-CAG, cognitive-predicted age minus chronological age), (2) composite scores for episodic memory (SA-EM), (3) non-memory cognition (SA-NM), and (4) the California Verbal Learning Test (SA-CVLT).
resultsFair to moderate strength of agreement was found between the four definitions. Most SA groups showed greater cortical thickness compared to typical aging (TA), especially in the anterior cingulate and midcingulate cortices and medial temporal lobes. Greater hippocampal volume was found in all SA groups except SA-NM. Lower entorhinal DISCUSSION: These findings suggest that a feature of SA, regardless of its exact definition, is resistance to tau pathology and preserved cortical integrity, especially in the anterior cingulate and midcingulate cortices. HIGHLIGHTS: Different approaches have been used to define successful cognitive aging (SA). Regardless of definition, different SA groups have similar brain features. SA individuals have greater anterior cingulate thickness and hippocampal volume. Lower entorhinal tau deposition, but not amyloid beta is related to SA. A combination of cortical integrity and resistance to tau may be features of SA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.