ArticleJournal of internal medicine2024
Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.
Article in Journal of internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Cardiovascular disease, 24-h movement behaviors and all-cause mortality: a compositional mediation analysis based on a prospective cohort.Journal of exercise science and fitness · 2026Article
- Sex disparities in the associations between accelerometer-measured movement behaviors and subsequent thromboembolism risk in cancer patients.Biology of sex differences · 2026Article
- Device-Measured Physical Activity, Sedentary Behaviour and Risk of Chronic Kidney Diseases Across Levels of Grip Strength.Journal of cachexia, sarcopenia and muscle · 2025Article
- Interaction of accelerometer-measured physical activity and genetic risk on cardiovascular diseases: a prospective cohort study from UK Biobank.BMJ open sport & exercise medicine · 2025Article
- Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease.Scientific reports · 2024Article
- Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.Journal of internal medicine · 2024Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundExcess sedentary time (ST) is recognized as an important modifiable risk factor for coronary heart disease (CHD). However, whether the associations of genetic susceptibility with CHD incidence can be modified by replacing wearable-device-measured ST with physical activity (PA) is unknown.
objectivesTo examine the associations of wearable-device-measured ST replaced by PA with incident CHD across strata of genetic susceptibility.
methodsThis study included 77,500 White British (57% female) with valid wrist-worn accelerometry and without prevalent CHD/stroke from UK Biobank. Genetic susceptibility to CHD was quantified through weighted polygenic risk scores for CHD based on 300 single-nucleotide polymorphisms. Wrist-worn accelerometer data were used to derive ST, light PA, and moderate-to-vigorous PA (MVPA).
resultsReallocation of 60 min/day of ST into the same amount of MVPA was associated with approximately 9% lower relative risk of CHD for all participants and across strata of genetic risk: replacement of 1 min/day of ST associated with <1% lower relative risk of CHD. No evidence of interaction (p: 0.784) was found between genetic risk and ST for CHD risk. Reallocating 60 min/day of ST into the same MVPA time was associated with greater absolute CHD risk reductions at high genetic risk (0.27%) versus low genetic risk (0.15%).
conclusionsReplacing any amount of ST with an equal amount of MVPA time is associated with a lower relative risk of CHD, irrespective of genetic susceptibility to CHD. Reductions in CHD absolute risk for replacing ST with MVPA are greater at high genetic risk versus low genetic risk.
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