Evidence map›Paper›PMID 37614038›Full record

ArticleAutophagy2024

Autophagy preserves hematopoietic stem cells by restraining MTORC1-mediated cellular anabolism.

Mariana Borsa, Sandrine Obba, Felix C Richter, Hanlin Zhang, Thomas Riffelmacher, Joana Carrelha, Ghada Alsaleh, Sten Eirik W Jacobsen, Anna Katharina Simon

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

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  18. The role of autophagy in pancreatic diseases.Frontiers in pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Mariana BorsaKennedy Institute of Rheumatology NDORMS, University of Oxford, Oxford, UK.
Sandrine ObbaKennedy Institute of Rheumatology NDORMS, University of Oxford, Oxford, UK.
Felix C RichterKennedy Institute of Rheumatology NDORMS, University of Oxford, Oxford, UK.
Hanlin ZhangKennedy Institute of Rheumatology NDORMS, University of Oxford, Oxford, UK.
Thomas RiffelmacherKennedy Institute of Rheumatology NDORMS, University of Oxford, Oxford, UK.
Joana CarrelhaMRC Molecular Haematology Unit, MRC WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Ghada AlsalehKennedy Institute of Rheumatology NDORMS, University of Oxford, Oxford, UK.
Sten Eirik W JacobsenMRC Molecular Haematology Unit, MRC WIMM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Anna Katharina SimonKennedy Institute of Rheumatology NDORMS, University of Oxford, Oxford, UK.
University of Oxford · GBMRC Human Immunology Unit · GB

Funding

Medical Research Council G0801073Medical Research Council MC_UU_00016/5Medical Research Council MC_UU_12009/5Versus Arthritis 22617Wellcome Trust
6 · The paper itself

Abstract

Adult stem cells are long-lived and quiescent with unique metabolic requirements. Macroautophagy/autophagy is a fundamental survival mechanism that allows cells to adapt to metabolic changes by degrading and recycling intracellular components. Here we address why autophagy depletion leads to a drastic loss of the stem cell compartment. Using inducible deletion of autophagy specifically in adult hematopoietic stem cells (HSCs) and in mice chimeric for autophagy-deficient and normal HSCs, we demonstrate that the stem cell loss is cell-intrinsic. Mechanistically, autophagy-deficient HSCs showed higher expression of several amino acid transporters (AAT) when compared to autophagy-competent cells, resulting in increased amino acid (AA) uptake. This was followed by sustained MTOR (mechanistic target of rapamycin) activation, with enlarged cell size, glucose uptake and translation, which is detrimental to the quiescent HSCs. MTOR inhibition by rapamycin treatment

Indexed as

AutophagySignal TransductionAnimalsHematopoietic Stem CellsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MicePhosphatidylinositol 3-KinasesSirolimusMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Phosphatidylinositol 3-KinasesSirolimusamino acidsAutophagyhematopoietic stem cellsMTORrapamycintranslation

Identifiers

PMID37614038
PMCPMC10761185
OpenAlexW4386116094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.