Evidence map›Paper›PMID 37612789›Full record

ArticleAnalytical chemistry2023

Fluorescent Nanodiamonds for Tracking Single Polymer Particles in Cells and Tissues.

Runrun Li, Thea A Vedelaar, Alina Sigaeva, Yue Zhang, Kaiqi Wu, Hui Wang, Xixi Wu, Peter Olinga, Małgorzata K Wlodarzyk-Biegun, Romana Schirhagl

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Runrun LiDepartment of Biomedical Engineering, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Thea A VedelaarDepartment of Biomedical Engineering, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Alina SigaevaDepartment of Biomedical Engineering, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Yue ZhangDepartment of Biomedical Engineering, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Kaiqi WuDepartment of Biomedical Engineering, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Hui WangZernike Institute for Advanced Materials, Groningen University, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Xixi WuDepartment of Biomedical Engineering, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Peter OlingaDepartment of Pharmaceutical Technology and Biopharmacy, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Małgorzata K Wlodarzyk-BiegunZernike Institute for Advanced Materials, Groningen University, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Romana SchirhaglDepartment of Biomedical Engineering, Groningen University, University Medical Center Groningen, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.ORCID 0000-0002-8749-1054
University Medical Center Groningen · NLSilesian University of Technology · PLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymer nanoparticles are widely used in drug delivery and are also a potential concern due to the increased burden of nano- or microplastics in the environment. In order to use polymer nanoparticles safely and understand their mechanism of action, it is useful to know where within cells and tissues they end up. To this end, we labeled polymer nanoparticles with nanodiamond particles. More specifically, we have embedded nanodiamond particles in the polymer particles and characterized the composites. Compared to conventional fluorescent dyes, these labels have the advantage that nanodiamonds do not bleach or blink, thus allowing long-term imaging and tracking of polymer particles. We have demonstrated this principle both in cells and entire liver tissues.

Indexed as

NanodiamondsDrug Delivery SystemsFluorescent DyesPlasticsPolymersFluorescent DyesNanodiamondsPlasticsPolymers

Identifiers

PMID37612789
PMCPMC10483464
OpenAlexW4386116734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.