Evidence map›Paper›PMID 37612689›Full record

ReviewJournal of nanobiotechnology2023

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis.

Fan Zhiguo, Wu Ji, Chen Shenyuan, Zhang Guoyou, Kai Chen, Qian Hui, Xu Wenrong, Xiao Zhai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fan Zhiguo *Department of Orthopedics, Shanghai Changhai Hospital, Shanghai, 200433, China.
Wu Ji *Department of Orthopedics, Shanghai Changhai Hospital, Shanghai, 200433, China.
Chen Shenyuan *Key Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, China.
Zhang Guoyou *Department of Orthopedics, Shanghai Changhai Hospital, Shanghai, 200433, China.
Kai ChenDepartment of Orthopedics, Shanghai Changhai Hospital, Shanghai, 200433, China. ch_kai@163.com.
Qian HuiKey Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, China. lstmmmlst@163.com.
Xu WenrongKey Laboratory of Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, China. icls@ujs.edu.cn.
Xiao ZhaiDepartment of Orthopedics, Shanghai Changhai Hospital, Shanghai, 200433, China. drzhaixiao@126.com.

Funding

National Natural Science Foundation of China 81701199Shanghai Municipal Health Commission 2022YQ003
6 · The paper itself

Abstract

Extracellular vesicles (EVs) in the field of spinal cord injury (SCI) have garnered significant attention for their potential applications in diagnosis and therapy. However, no bibliometric assessment has been conducted to evaluate the scientific progress in this area. A search of articles in Web of Science (WoS) from January 1, 1991, to May 1, 2023, yielded 359 papers that were analyzed using various online analysis tools. These articles have been cited 10,842 times with 30.2 times per paper. The number of publications experienced explosive growth starting in 2015. China and the United States led this research initiative. Keywords were divided into 3 clusters, including "Pathophysiology of SCI", "Bioactive components of EVs", and "Therapeutic effects of EVs in SCI". By integrating the average appearing year (AAY) of keywords in VoSviewer with the time zone map of the Citation Explosion in CiteSpace, the focal point of research has undergone a transformative shift. The emphasis has moved away from pathophysiological factors such as "axon", "vesicle", and "glial cell" to more mechanistic and applied domains such as "activation", "pathways", "hydrogels" and "therapy". In conclusions, institutions are expected to allocate more resources towards EVs-loaded hydrogel therapy and the utilization of innovative materials for injury mitigation.

Indexed as

Extracellular VesiclesSpinal Cord InjuriesAxonsBibliometricsHumansHydrogelsHydrogelsBibliometricCitationExtracellular vesiclesH-indexHotspotsSpinal cord injury

Identifiers

PMID37612689
PMCPMC10463993

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.