ArticleBMC medicine2023
Alcohol exposure before and during pregnancy is associated with reduced fetal growth: the Safe Passage Study.
Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 0 citations in OpenAlex.
- Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- The Population-Attributable Fractions of Small-for-Gestational-Age Births: Results from the Japan Birth Cohort Consortium.Nutrients · 2024Pooled it
- Participant experiences with a text message and contingency management intervention for alcohol use during pregnancy and lactation in Cape Town, South Africa.Addiction science & clinical practice · 2025Trial
- Potential for primary prevention of low birth weight in pregnancies with and without gestational diabetes mellitus: a prospective cohort study in Central China.BMC pregnancy and childbirth · 2026Article
- Does a Biochemical Approach Facilitate the Diagnosis of Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder in Neonatal Period?International journal of molecular sciences · 2026Review
- Periconceptional ultra-processed food consumption in women and men, fertility, and early embryonic development.Human reproduction (Oxford, England) · 2026Article
- Establishment and validation of a prediction model for small vulnerable newborns: a retrospective study.Journal of global health · 2025Article
- Weighing up the evidence on ethanol excipient use in common neonatal medications.Pediatric research · 2025Article
- Health behaviors in women conceiving by medically assisted reproduction vs natural conception: A cross-sectional study of 23,334 nulliparous women.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Smoking and Alcohol During Pregnancy: Effects on Fetal and Neonatal Health-A Pilot Study.Journal of clinical medicine · 2025Article
- Early life outcomes of prenatal exposure to alcohol and synthetic cannabinoids in mice.Drug and alcohol dependence reports · 2025Article
- Sequelae of preterm birth over the lifespan: an exploratory analysis of behavioral problems in childhood and increased risk of major depression and anxiety in adulthood from a cohort study.EClinicalMedicine · 2025Article
- Smoking During Pregnancy and Its Association with Maternal Health Among Women of Reproductive Age in Alabama: An Analysis Using the Three Delays Model and PRAMS Phase 8 Data.Healthcare (Basel, Switzerland) · 2025Article
- Early Life Outcomes of Prenatal Exposure to Alcohol and Synthetic Cannabinoids in Mice.bioRxiv : the preprint server for biology · 2025Article
- Alcohol, Tobacco and Illicit Drug Use During Pregnancy in the Longitudinal BELpREG Cohort in Belgium Between 2022 and 2024.Journal of clinical medicine · 2025Article
- Article
- Exploring Nutritional Status and Metabolic Imbalances in Children with FASD: A Cross-Sectional Study.Nutrients · 2024Article
- Alcohol intake during pregnancy reduces offspring bone epiphyseal growth plate chondrocyte proliferation through transforming growth factor β-1 inhibition in the Sprague Dawley rat humerus.Anatomy & cell biology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPrenatal alcohol exposure (PAE) is a worldwide public health concern. While PAE is known to be associated with low birth weight, little is known about timing and quantity of PAE on fetal growth. This study investigated the association between periconceptional and prenatal alcohol exposure and longitudinal fetal growth, focusing on timing and quantity in a high exposure cohort.
methodsThe Safe Passage Study was a prospective cohort study, including 1698 pregnant women. Two-dimensional transabdominal ultrasound examinations were performed to measure fetal femur length, abdominal and head circumference, and biparietal diameter, at three time points during pregnancy. Estimated fetal weight and Z-scores of all parameters were calculated. Trimester-specific alcohol exposure was assessed using the Timeline Followback method. To investigate the associations of specific timing of PAE and fetal growth, two models were built. One with alcohol exposure as accumulative parameter over the course of pregnancy and one trimester specific model, in which PAE was separately analyzed. Linear mixed models adjusted for potential confounders were applied with repeated assessments of both alcohol exposure and fetal growth outcomes.
resultsThis study demonstrated that periconceptional and prenatal alcohol exposure were associated with reduced fetal growth. Effect sizes are displayed as estimated differences (ED) in Z-score and corresponding 95% confidence intervals (95% CIs). When investigated as accumulative parameter, PAE was related to a smaller femur length (ED
conclusionsThis study demonstrated that PAE negatively affects fetal growth, in particular when exposed during the periconception period or in second trimester. Our results indicate that potential negative consequences of PAE are detectable already before birth. Therefore, healthcare providers should actively address and discourage alcohol use during pregnancy.
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