Evidence map›Paper›PMID 37612506›Full record

ArticleNature2023

OPA1 helical structures give perspective to mitochondrial dysfunction.

Sarah B Nyenhuis, Xufeng Wu, Marie-Paule Strub, Yang-In Yim, Abigail E Stanton, Valentina Baena, Zulfeqhar A Syed, Bertram Canagarajah, John A Hammer, Jenny E Hinshaw

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  12. A membrane insertion code for intrinsically disordered proteins.bioRxiv : the preprint server for biology · 2026
    Article
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  19. Conformational Rearrangement of Fission DSPs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sarah B NyenhuisLaboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.ORCID 0000-0002-3139-4423
Xufeng WuLight Microscopy Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Marie-Paule StrubProtein Expression Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Yang-In YimCell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Abigail E StantonLaboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Valentina BaenaElectron Microscopy Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-6429-439X
Zulfeqhar A SyedElectron Microscopy Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-5825-9782
Bertram CanagarajahLaboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
John A HammerCell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Jenny E HinshawLaboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA. jennyh@niddk.nih.gov.ORCID 0000-0002-5130-5061
National Heart Lung and Blood Institute · USNational Institute of Diabetes and Digestive and Kidney Diseases · USPrinceton University · USProtein Express (United States) · US

Funding

Electron Microscopy CoreZICHL005906 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SYED, ZULFEQHAR · 2009 to 2025
$12.9M
Structural analysis of dynamins involved in mitochondrial morphologyZIADK060107 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HINSHAW, JENNY E · 2009 to 2025
$10.6M
Intramural NIH HHS ZIA DK060107
6 · The paper itself

Abstract

Dominant optic atrophy is one of the leading causes of childhood blindness. Around 60-80% of cases

Indexed as

Cryoelectron MicroscopyGTP PhosphohydrolasesMitochondriaHumansMembrane FusionMitochondrial DynamicsMitochondrial MembranesMutationNucleotidesProtein BindingProtein DomainsProtein FoldingProtein MultimerizationProtein Structure, SecondaryGTP PhosphohydrolasesNucleotidesOPA1 protein, human

Identifiers

PMID37612506
PMCPMC12410014
OpenAlexW4386100748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.