Evidence map›Paper›PMID 37612504›Full record

ArticleNature2023

Structural mechanism of mitochondrial membrane remodelling by human OPA1.

Alexander von der Malsburg, Gracie M Sapp, Kelly E Zuccaro, Alexander von Appen, Frank R Moss, Raghav Kalia, Jeremy A Bennett, Luciano A Abriata, Matteo Dal Peraro, Martin van der Laan and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Alexander von der MalsburgMedical Biochemistry & Molecular Biology, Center for Molecular Signaling, PZMS, Saarland University Medical School, Homburg, Germany.
Gracie M SappDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Kelly E ZuccaroDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Alexander von AppenDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6528-2123
Frank R MossDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Raghav KaliaDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Jeremy A BennettDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA.
Luciano A AbriataInstitute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0003-3087-8677
Matteo Dal PeraroInstitute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-2973-3975
Martin van der LaanMedical Biochemistry & Molecular Biology, Center for Molecular Signaling, PZMS, Saarland University Medical School, Homburg, Germany.ORCID 0000-0003-0789-9912
Adam FrostDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. afrost@altoslabs.com.ORCID 0000-0003-2231-2577
Halil AydinDepartment of Biochemistry, University of Colorado Boulder, Boulder, CO, USA. halil.aydin@colorado.edu.ORCID 0000-0002-5409-3797
University of Colorado Boulder · USUniversity of California, San Francisco · USSaarland University · DESIB Swiss Institute of Bioinformatics · CHQB3 · US

Funding

Regulation of mitochondrial morphology and functional versatilityR35GM150942 · NIGMS · UNIVERSITY OF COLORADO · PI HALIL AYDIN · 2023 to 2026
$1.6M
Regulated Mitochondrial MorphologyR01GM127673 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BULKLEY, DAVID · 2018 to 2021
$1.2M
NIGMS NIH HHS R01 GM127673NIGMS NIH HHS R35 GM150942
6 · The paper itself

Abstract

Distinct morphologies of the mitochondrial network support divergent metabolic and regulatory processes that determine cell function and fate

Indexed as

GTP PhosphohydrolasesMembrane FusionMitochondriaMitochondrial MembranesBiocatalysisCardiolipinsHumansMitochondrial DynamicsMutationProtein DomainsProtein MultimerizationCardiolipinsGTP PhosphohydrolasesOPA1 protein, human

Identifiers

PMID37612504
PMCPMC10875962
OpenAlexW4386086719

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.