ArticleNature communications2023
A circuit suppressing retinal drive to the optokinetic system during fast image motion.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Natural motion statistics unify direction computations.bioRxiv : the preprint server for biology · 2026Article
- Synaptic Inputs to OFF Parasol Ganglion Cells in Macaque Retina: An Analysis Using Serial Blockface Scanning Electron Microscopy.Brain sciences · 2026Article
- Distinct inhibitory connectivity motifs could trigger distinct forms of anticipation in the retinal network.Scientific reports · 2026Article
- Machine learning discovers numerous new computational principles supporting elementary motion detection.Nature communications · 2026Article
- Amacrine cell inputs to OFF midget ganglion cells in macaque retina.The Journal of physiology · 2025Article
- Limited transmission of mixed convergent signals at the mouse retinogeniculate synapse.Neuron · 2025Article
- Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific manner.Cell reports · 2025Article
- Diverse and dynamic influences of saccades on visual representations in the mouse superior colliculus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Layer-specific anatomical and physiological features of the retina's neurovascular unit.Current biology : CB · 2025Article
- Changes in glycinergic neurotransmission alter mammalian retinal information processing.Frontiers in molecular neuroscience · 2025Article
- Asymmetries in the Architecture of ON and OFF Arbors in ON-OFF Direction-Selective Ganglion Cells.The Journal of comparative neurology · 2025Article
- Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Presynaptic Proteins and Their Roles in Visual Processing by the Retina.Annual review of vision science · 2024Review
- Differential Expression Analysis Identifies Candidate Synaptogenic Molecules for Wiring Direction-Selective Circuits in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.eLife · 2023Article
- Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.bioRxiv : the preprint server for biology · 2023Article
- A circuit suppressing retinal drive to the optokinetic system during fast image motion.Nature communications · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Optokinetic nystagmus (OKN) assists stabilization of the retinal image during head rotation. OKN is driven by ON direction selective retinal ganglion cells (ON DSGCs), which encode both the direction and speed of global retinal slip. The synaptic circuits responsible for the direction selectivity of ON DSGCs are well understood, but those sculpting their slow-speed preference remain enigmatic. Here, we probe this mechanism in mouse retina through patch clamp recordings, functional imaging, genetic manipulation, and electron microscopic reconstructions. We confirm earlier evidence that feedforward glycinergic inhibition is the main suppressor of ON DSGC responses to fast motion, and reveal the source for this inhibition-the VGluT3 amacrine cell, a dual neurotransmitter, excitatory/inhibitory interneuron. Together, our results identify a role for VGluT3 cells in limiting the speed range of OKN. More broadly, they suggest VGluT3 cells shape the response of many retinal cell types to fast motion, suppressing it in some while enhancing it in others.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.