Evidence map›Paper›PMID 37612174›Full record

ArticleBrachytherapy

Feasibility of quantitative diffusion-weighted imaging during intra-procedural MRI-guided brachytherapy of locally advanced cervical and vaginal cancers.

Megan C Jacobsen, Bastien Rigaud, Samantha J Simiele, Gaiane M Rauch, Matthew S Ning, Sastry Vedam, Ann H Klopp, R Jason Stafford, Kristy K Brock, Aradhana M Venkatesan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brachytherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Megan C JacobsenDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: mcjacobsen@mdanderson.org.
Bastien RigaudDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Samantha J SimieleDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Gaiane M RauchDepartment of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.
Matthew S NingDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Sastry VedamUniversity of Maryland, Department of Radiation Oncology, Baltimore, MD.
Ann H KloppDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
R Jason StaffordDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Kristy K BrockDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Aradhana M VenkatesanDepartment of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: avenkatesan@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USUniversity of Maryland, Baltimore · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

purposeTo determine the feasibility of quantitative apparent diffusion coefficient (ADC) acquisition during magnetic resonance imaging-guided brachytherapy (MRgBT) using reduced field-of-view (rFOV) diffusion-weighted imaging (DWI). METHODS AND MATERIALS: T2-weighted (T2w) MR and full-FOV single-shot echo planar (ssEPI) DWI were acquired in 7 patients with cervical or vaginal malignancy at baseline and prior to brachytherapy, while rFOV-DWI was acquired during MRgBT following brachytherapy applicator placement. The gross target volume (GTV) was contoured on the T2w images and registered to the ADC map. Voxels at the GTV's maximum Maurer distance comprised a central sub-volume (GTV

resultsssEPI-DWI mean ADC increased between baseline and prebrachytherapy from 1.03 ± 0.18 10

conclusionsQuantitative ADC measurement in the setting of MRI guided brachytherapy implant placement for cervical and vaginal cancers is feasible using rFOV-DWI, with comparable mean ADC comparable to prebrachytherapy ssEPI-DWI, and may enable MRI-guided radiotherapy targeting of low ADC, radiation resistant sub-volumes of tumor.

Indexed as

BrachytherapyVaginal NeoplasmsDiffusion Magnetic Resonance ImagingFeasibility StudiesFemaleHumansReproducibility of Resultsapparent diffusion coefficientbrachytherapycervical cancerdiffusion-weighted imagingvaginal cancer

Identifiers

PMID37612174
PMCPMC11798583
OpenAlexW4386034334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.