Evidence map›Paper›PMID 37612053›Full record

ArticleStroke and vascular neurology2024

Cerebral venous sinus thrombosis: changing trends in the incidence, age and gender (findings from the CMC Vellore CVT registry).

Angel Miraclin T, John Davis Prasad, George Abraham Ninan, Mahasampath Gowri, Deepti Bal, Atif Iqbal Ahmed Shaikh, Rohit N Benjamin, Appaswamy Thirumal Prabhakar, Ajith Sivadasan, Vivek Mathew and 1 more

Abstract readComparative Study
In one paragraph

Article in Stroke and vascular neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angel Miraclin TDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0000-0002-6536-9170
John Davis PrasadDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
George Abraham NinanDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Mahasampath GowriDepartment of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
Deepti BalDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Atif Iqbal Ahmed ShaikhDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Rohit N BenjaminDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Appaswamy Thirumal PrabhakarDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.ORCID 0000-0003-2008-1808
Ajith SivadasanDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Vivek MathewDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Sanjith AaronDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India sanjith@cmcvellore.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple cerebral venous sinus thrombosis (CVT) registries from various geographical regions indicate that female gender, the use of contraceptive pills, pregnancy and puerperium are important risk factors. In this study, we report the changes in the epidemiology of patients with CVT managed over the past 26 years.

methodsThe CMC Vellore CVT registry is a prospectively maintained database at the Christian Medical College, Vellore since January 1995. Stata software was used to analyse the data and assess the changes in the incidence, age and gender distribution over the previous 26 years.

resultsAmong 1701 patients treated during the study period, 908 (53%) were women and 793 (47%) were men. The mean incidence of CVT was 49 per 100 000 admissions before 2010, which increased to 96 per 100 000 after 2010. Male gender had a higher odds of developing CVT (OR - 2.07 (CI 1.68 to 2.55, p<0.001). This could be attributed to the declining incidence of postpartum CVT after 2010 compared with the decade before 2010 (50% vs 20%). The mean age at presentation had increased from 24.5 to 33.2 years in the last decade.

conclusionsThere was a clear change in the gender pattern from being a condition with female preponderance, to one where equal or more men are being affected. Lower incidence of postpartum CVT cases could be the driving factor. An increase in the overall incidence of CVT cases was noted, probably due to a higher index of clinical suspicion and better diagnostic imaging modalities.

Indexed as

RegistriesSinus Thrombosis, IntracranialAdolescentAdultAgedAge DistributionAge FactorsFemaleHumansIncidenceMaleMiddle AgedRisk AssessmentRisk FactorsSex DistributionSex FactorsCerebrovascular Disorders

Identifiers

PMID37612053
PMCPMC11221320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.