Evidence map›Paper›PMID 37611818›Full record

Trial reportJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2023

Factors associated with visual acuity improvement with a binocular digital therapeutic for amblyopia.

Isdin Oke, Eric D Gaier, Michael X Repka

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Isdin OkeDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: Isdin.Oke@childrens.harvard.edu.
Eric D GaierPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Michael X RepkaWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.

Funding

Training in Child Health Services Research and Implementation ScienceT32HS000063 · AHRQ · CHILDREN'S HOSPITAL BOSTON · PI GARABEDIAN, LAURA FADEN, WALSH, KATHLEEN ELIZABETH · 1994 to 2024
$7.6M
Exploiting principles of timing-dependent synaptic plasticity to treat amblyopiaK08EY030164 · NEI · BOSTON CHILDREN'S HOSPITAL · PI GAIER, ERIC DEAN · 2019 to 2023
$1.2M
AHRQ HHS T32 HS000063NEI NIH HHS K08 EY030164
6 · The paper itself

Abstract

We combined data from 121 amblyopic children enrolled in two prospective open-label pilot studies and a randomized trial of a binocular digital therapeutic to identify factors associated with positive response to amblyopia treatment. Visual acuity improved ≥1 line in 81% of participants after 12 weeks of therapy. Treatment response was not found to be associated with age, severity of amblyopia, or prior treatment status. Although these findings may suggest broad efficacy for this treatment approach, further investigation in larger cohorts is needed to identify factors associated with treatment response.

Indexed as

AmblyopiaVideo GamesChildChild, PreschoolFollow-Up StudiesHumansProspective StudiesTreatment OutcomeVision, BinocularVisual Acuity

Identifiers

PMID37611818
PMCPMC11867222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.