Evidence map›Paper›PMID 37611749›Full record

ArticleOphthalmology. Glaucoma

Anterior Segment OCT for Detection of Narrow Angles: A Community-Based Diagnostic Accuracy Study.

Sangita Pradhan, Ranjeet K Sah, Gopal Bhandari, Sadhan Bhandari, Raghunandan Byanju, Ram P Kandel, Isabel J B Thompson, Valerie M Stevens, Krisianne M Aromin, Julius T Oatts and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology. Glaucoma. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Enhanced Imaging of Ocular Surface Lesions.Journal of clinical medicine · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Sangita PradhanBharatpur Eye Hospital, Bharatpur, Nepal.
Ranjeet K SahBharatpur Eye Hospital, Bharatpur, Nepal.
Gopal BhandariBharatpur Eye Hospital, Bharatpur, Nepal.
Sadhan BhandariBharatpur Eye Hospital, Bharatpur, Nepal.
Raghunandan ByanjuBharatpur Eye Hospital, Bharatpur, Nepal.
Ram P KandelSeva Foundation, Berkeley, California.
Isabel J B ThompsonFrancis I. Proctor Foundation, University of California, San Francisco, California.
Valerie M StevensFrancis I. Proctor Foundation, University of California, San Francisco, California.
Krisianne M ArominFrancis I. Proctor Foundation, University of California, San Francisco, California.
Julius T OattsDepartment of Ophthalmology, University of California San Francisco, San Francisco, California.
Yvonne OuDepartment of Ophthalmology, University of California San Francisco, San Francisco, California.
Thomas M LietmanFrancis I. Proctor Foundation, University of California, San Francisco, California; Department of Ophthalmology, University of California San Francisco, San Francisco, California; Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California; Institute for Global Health Sciences, University of California San Francisco, San Francisco, California.
Kieran S O'BrienFrancis I. Proctor Foundation, University of California, San Francisco, California; Department of Ophthalmology, University of California San Francisco, San Francisco, California.
Jeremy D KeenanFrancis I. Proctor Foundation, University of California, San Francisco, California; Department of Ophthalmology, University of California San Francisco, San Francisco, California. Electronic address: jeremy.keenan@ucsf.edu.
University of California, San Francisco · USBiratnagar Eye Hospital · NPSeva Foundation · US

Funding

Village-Integrated Eye Worker trial II (VIEW II)UG1EY028097 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEENAN, JEREMY DAVID · 2018 to 2023
$2.9M
NEI NIH HHS UG1 EY028097
6 · The paper itself

Abstract

purposeTo assess the diagnostic accuracy of anterior segment OCT (AS-OCT) screening for detecting gonioscopically narrow angles.

designPopulation-based cross-sectional study.

participantsA stratified random sample of individuals aged ≥ 60 years, selected from a door-to-door census performed in low-lying Nepal. TESTING: Participants underwent AS-OCT, posterior segment OCT, and intraocular pressure (IOP) testing in the community. Those meeting referral criteria in either eye were invited to have a comprehensive eye examination including gonioscopy. Referral criteria included (i) the lowest 2.5% of AS-OCT measurements, (ii) retinal OCT results suggestive of glaucomatous optic neuropathy, diabetic retinopathy, or age-related macular degeneration, and (iii) elevated IOP.

main outcome measuresSensitivity and specificity of 5 semiautomated AS-OCT parameters relative to gonioscopically narrow angles, defined as the absence of visible trabecular meshwork for ≥ 180° on nonindentation gonioscopy.

resultsOf 17 656 people aged ≥ 60 years enumerated from 102 communities, 12 633 (71.6%) presented for AS-OCT testing. Referral was recommended for 697 participants based on AS-OCT criteria and 2419 participants based on other criteria, of which 858 had gonioscopy performed by a glaucoma specialist. Each of the 5 AS-OCT parameters offered good diagnostic information for predicting eyes with gonioscopically narrow angles, with areas under the receiver operating characteristic curve ranging from 0.85 to 0.89. The angle opening distance at 750 μm from the scleral spur (AOD750) provided the most diagnostic information, providing an optimal sensitivity of 87% (95% confidence interval [CI], 75%-96%) and specificity of 77% (71%-83%) at a cutpoint of 367 μm, and a sensitivity of 65% (95% CI, 54%-74%) when specificity was constrained to 90% (cutpoint, 283 μm).

conclusionsOn AS-OCT, the AOD750 parameter detected approximately two-thirds of cases of gonioscopically narrow angles when test specificity was set to 90%. Although such a sensitivity may not be sufficient when screening solely for narrow angles, AS-OCT requires little additional effort if posterior segment OCT is already being performed and thus could provide incremental benefit when performing OCT-based screening. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

GlaucomaGlaucoma, Angle-ClosureCross-Sectional StudiesHumansSensitivity and SpecificityTomography, Optical CoherenceTrabecular MeshworkAnterior eye segmentGlaucoma, angle-closureSensitivity and specificityTomography, optical

Identifiers

PMID37611749
PMCPMC11572148
OpenAlexW4386034681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.