Evidence map›Paper›PMID 37611534›Full record

ArticleEuropean journal of medicinal chemistry2023

Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity.

Sara Elsayed, Ahmed S Abdelkhalek, Samar Rezq, Mansour E Abu Kull, Damian G Romero, Hend Kothayer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Exploring the Action Mechanism and Validation of the Key Pathways ofCombinatorial chemistry & high throughput screening · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sara ElsayedMedicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Ahmed S AbdelkhalekMedicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Samar RezqDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt; Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA; Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS, USA; Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS, USA; Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS, USA.
Mansour E Abu KullMedicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Damian G RomeroDepartment of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA; Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS, USA; Women's Health Research Center, University of Mississippi Medical Center, Jackson, MS, USA; Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS, USA.
Hend KothayerMedicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt. Electronic address: hendo1311@hotmail.com.
Zagazig University · EGJackson Memorial Hospital · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Emerging evidence points to the intertwining framework of inflammation and oxidative stress in various ailments. We speculate on the potential impact of the magic shotgun approach in these ailments as an attempt to mitigate the drawbacks of current NSAIDs. Hence, we rationally designed and synthesized new tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine monomers/heterodimer as dual selective COX-2/15-LOX inhibitors with potent antioxidant activity. The synthesized compounds were challenged with diverse in vitro biological assays. Regarding the monomeric series, compound 5k exerted the highest COX-2 inhibitory activity (IC

Indexed as

Anti-Inflammatory AgentsAntioxidantsInterleukin-6Lipoxygenase InhibitorsPyrimidinesArachidonate 15-LipoxygenaseCyclooxygenase 2Cyclooxygenase 2 InhibitorsReactive Oxygen SpeciesTumor Necrosis Factor-alphaALOX15 protein, humanAnti-Inflammatory AgentsAntioxidantsArachidonate 15-LipoxygenaseCyclooxygenase 2Cyclooxygenase 2 InhibitorsInterleukin-6Lipoxygenase InhibitorsPyrimidinesReactive Oxygen Speciestetrahydrobenzo(4,5)thieno(2,3-d)pyrimidinethienopyrimidineTumor Necrosis Factor-alphaAntioxidantDual COX-2/15-LOX inhibitorsHeterodimerInflammationThienopyrimidine

Identifiers

PMID37611534
PMCPMC10528942
OpenAlexW4385830751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.