Evidence map›Paper›PMID 37611510›Full record

ArticleParkinsonism & related disorders2023

Diet quality and Parkinson's disease: Potential strategies for non-motor symptom management.

Dayoon Kwon, Aline D Folle, Irish Del Rosario, Keren Zhang, Kimberly C Paul, Adrienne M Keener, Jeff M Bronstein, Beate Ritz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Healthy Dietary Patterns and Risk of Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. Article
  5. Article
  6. Lifestyle medicine in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Observational
  12. Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dayoon KwonDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Aline D FolleDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Irish Del RosarioDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Keren ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Kimberly C PaulDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Adrienne M KeenerDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Jeff M BronsteinDepartment of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Beate RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Neurology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: britz@ucla.edu.
UCLA Health · USUniversity of California, Los Angeles · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
UCLA CENTER FOR THE STUDY OF PARKINSON'S DISEASEP50NS038367 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 1999 to 2011
$15.3M
Center for Gene-Environment Studies in Parkinson DiseaseU54ES012078 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 2002 to 2006
$7.1M
Project 4: Pesticides and Genes In PD: Studies In HumansP01ES016732 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 2008 to 2012
$6.7M
PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Microbiome, Pesticides and Parkinsons in LatinosR01ES031106 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2020 to 2025
$3.8M
NIEHS NIH HHS P01 ES016732NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES010544NIEHS NIH HHS R01 ES031106NIEHS NIH HHS U54 ES012078NINDS NIH HHS P50 NS038367
6 · The paper itself

Abstract

introductionParkinson's disease (PD) is now considered a systemic disease, and some phenotypes may be modifiable by diet. We will compare the diet quality and intake of specific nutrients and food groups of PD patients with household and community controls to examine how diet may influence PD clinical features.

methodsWe conducted a case-control study of 98 PD patients and 83 controls (household = 53; community = 30) in central California, assessing dietary habits over the past month and calculating the Healthy Eating Index (HEI)-2015. We employed multivariate logistic and linear regression analyses to assess associations between diet and PD status, PD symptom profiles, and medication, adjusting for relevant confounders.

resultsPD patients had a lower HEI score than controls, with an OR of 0.65 (95% CI: 0.45, 0.94) per 10-points increase in HEI. Lower-quality diet was characterized by higher intakes of carbohydrates, total and added sugars, and trans fats and lower intakes of fiber, folate, unsaturated fatty acids, protein, and fat. PD patients with chronic constipation had a 4.84 point lower HEI score than those without (β per 10-point in HEI: -0.48; 95% CI: -0.97, -0.00). Furthermore, patients on high dopamine agonist doses consumed more sugar than those on lower doses.

conclusionPD patients consume a lower-quality diet compared to household and community controls. Dietary modifications may alleviate non-motor symptoms like constipation, and promoting a healthy diet should become a part of routine care and disease management for PD patients, with special attention on agonist-treated and hyposmic patients.

Indexed as

Parkinson DiseaseAgedCase-Control StudiesConstipationDietDiet, HealthyFeeding BehaviorFemaleHumansMaleMiddle AgedConstipationDiet qualityNutrientsParkinson’s diseasePhenotype

Identifiers

PMID37611510
PMCPMC11121503
OpenAlexW4386018773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.