Evidence map›Paper›PMID 37611509›Full record

ArticleParkinsonism & related disorders2023

Polygenic risk score for Parkinson's disease and olfaction among middle-aged to older women.

Zichun Cao, Dena G Hernandez, Chenxi Li, Joos Berghausen, Zhehui Luo, Hirotaka Iwaki, Aimee A D'Aloisio, Xuemei Huang, Jayant M Pinto, Dale P Sandler and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Zichun CaoDepartment of Epidemiology and Biostatistics, Michigan State University College of Human Medicine, East Lansing, MI, USA. Electronic address: zc@msu.edu.
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA. Electronic address: hernand@mail.nih.gov.
Chenxi LiDepartment of Epidemiology and Biostatistics, Michigan State University College of Human Medicine, East Lansing, MI, USA. Electronic address: cli@msu.edu.
Joos BerghausenDepartment of Pharmacology & Physiology, Georgetown University, Washington D.C., USA. Electronic address: jhb109@georgetown.edu.
Zhehui LuoDepartment of Epidemiology and Biostatistics, Michigan State University College of Human Medicine, East Lansing, MI, USA. Electronic address: zluo@msu.edu.
Hirotaka IwakiCenter for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: hirotaka@datatecnica.com.
Aimee A D'AloisioSocial & Scientific Systems, a DLH Holdings Corporation, Durham, NC, USA. Electronic address: aimee.daloisio@dlhcorp.com.
Xuemei HuangDepartment of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA. Electronic address: xuh15@psu.edu.
Jayant M PintoDepartment of Surgery, The University of Chicago, Chicago, IL, USA. Electronic address: jpinto@surgery.bsd.uchicago.edu.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: sandler@niehs.nih.gov.
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA; Center for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: singleta@mail.nih.gov.
Honglei ChenDepartment of Epidemiology and Biostatistics, Michigan State University College of Human Medicine, East Lansing, MI, USA. Electronic address: chenho19@msu.edu.
Michigan State University · USNational Institutes of Health · USGeorgetown University · USLabCorp (United States) · USNational Institute of Environmental Health Sciences · USNational Institute on Aging · USPennsylvania State University · USUniversity of Chicago · US

Funding

Pesticides, Olfaction, and Neurodegeneration Among US FarmersR01ES029227 · NIEHS · MICHIGAN STATE UNIVERSITY · PI CHEN, HONGLEI · 2019 to 2023
$5.0M
Poor sense of smell and the health of older adultsR01AG071517 · NIA · MICHIGAN STATE UNIVERSITY · PI HONGLEI CHEN · 2022 to 2026
$2.7M
Genome wide SNP analysis in Parkinson's diseaseZ01AG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW B · 2006 to 2008
$2.6M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Intramural NIH HHS Z01 AG000949Intramural NIH HHS Z01 ES044005NIA NIH HHS R01 AG071517NIEHS NIH HHS R01 ES029227
6 · The paper itself

Abstract

introductionOlfactory impairment and Parkinson's disease (PD) may share common genetic and environmental risk factors. This study investigates the association of a PD polygenic risk score (PRS) with olfaction, and whether the associations are modified by environmental exposures of PM

methodsThis analysis included 3358 women (aged 50-80) from the Sister Study with genetic data and results from the Brief Smell Identification Test (B-SIT) administered in 2018-2019. PD PRS was calculated using 90 single nucleotide polymorphisms. Olfactory impairment was defined with different B-SIT cutoffs, and PD diagnosis was adjudicated via expert review. We report odds ratios (ORs) and 95% confidence intervals (CIs) from multivariable logistic regression.

resultsAs expected, PD PRS was strongly associated with the odds of having PD (OR highest vs. lowest quartile = 3.79 (1.64, 8.73)). The highest PRS quartile was also associated with olfactory impairment, with OR ranging from 1.24 (0.98, 1.56) for a B-SIT cutoff of 9 to 1.42 (1.04, 1.92) for a cutoff of 6. For individual B-SIT items, the highest PRS quartile was generally associated with lower odds of correctly identifying the odorant, albeit only statistically significant for pineapple (0.72 (0.56, 0.94), soap (0.76 (0.58, 0.99)) and rose (0.70 (0.54, 0.92)). The association of PD PRS with olfactory impairment was not modified by airborne environmental exposures or smoking.

conclusionThese preliminary data suggest that high PD genetic susceptibility is associated with olfactory impairment in middle-aged and older women.

Indexed as

Olfaction DisordersParkinson DiseaseAgedFemaleHumansMiddle AgedRisk FactorsSmellSmokingGenetic susceptibilityOlfactory impairmentParkinson

Identifiers

PMID37611509
PMCPMC10592043
OpenAlexW4385858704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.