Evidence map›Paper›PMID 37611209›Full record

ArticleAdvanced healthcare materials2023

Biomechanics, Energetics, and Structural Basis of Rupture of Fibrin Networks.

Ranjini K Ramanujam, Farkhad Maksudov, Rustem I Litvinov, Chandrasekaran Nagaswami, John W Weisel, Valerie Tutwiler, Valeri Barsegov

Open access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Fibrin as a Versatile Fibrous Biopolymer.Sub-cellular biochemistry · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Deconstructing fibrin(ogen) structure.Journal of thrombosis and haemostasis : JTH · 2025
    Review
  7. Protofibril packing density of individual fibers alters fibrinolysis.Research and practice in thrombosis and haemostasis · 2025
    Article
  8. Article
  9. Dependence of clot structure and fibrinolysis on apixaban and clotting activator.Research and practice in thrombosis and haemostasis · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ranjini K RamanujamDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Farkhad MaksudovDepartment of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
Rustem I LitvinovDepartment of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Chandrasekaran NagaswamiDepartment of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
John W WeiselDepartment of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Valerie TutwilerDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.ORCID 0000-0003-1213-4447
Valeri BarsegovDepartment of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
University of Pennsylvania · USRutgers, The State University of New Jersey · USUniversity of Massachusetts Lowell · US

Funding

Mechanisms of mechano-chemical rupture of blood clots and thrombiR01HL148227 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PUROHIT, PRASHANT KISHORE · 2020 to 2023
$2.5M
Experiment-based multi-scale modeling of the tensile and compressive deformations of fibrinR01HL135254 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PUROHIT, PRASHANT KISHORE · 2017 to 2020
$1.6M
Systematic multidisciplinary approach to study traumatic bleeding as a complex structural and biomechanical problemR00HL148646 · NHLBI · RUTGERS, THE STATE UNIV OF N.J. · PI TUTWILER, VALERIE · 2020 to 2022
$747k
Scanning Electron MicroscopeS10OD018041 · OD · UNIVERSITY OF PENNSYLVANIA · PI WEISEL, JOHN W · 2014 to 2014
$382k
NHLBI NIH HHS R00 HL148646NHLBI NIH HHS R01 HL135254NHLBI NIH HHS R01 HL148227NIH HHS S10 OD018041
6 · The paper itself

Abstract

Fibrin provides the main structural integrity and mechanical strength to blood clots. Failure of fibrin clots can result in life-threating complications, such as stroke or pulmonary embolism. The dependence of rupture resistance of fibrin networks (uncracked and cracked) on fibrin(ogen) concentrations in the (patho)physiological 1-5 g L

Indexed as

HemostaticsThrombosisBiomechanical PhenomenaFibrinFibrinogenHumansFibrinFibrinogenHemostaticsenergetics of rupturesfluctuating spring modelrupture of fibrin clotsstress-strain curves

Identifiers

PMID37611209
PMCPMC11468835
OpenAlexW4386090161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.